INTERPLAY BETWEEN IMMUNITY AND AMYOTROPHIC LATERAL SCLEROSIS: CLINICAL IMPACT

Details

• Alternative Title:
  Neurosci Biobehav Rev
• Personal Author:
  De Marchi, Fabiola ; Munitic, Ivana ; Amedei, Amedeo ; Berry, James D. ; Feldman, Eva L. ; Aronica, Eleonora ; Nardo, Giovanni ; Van Weehaeghe, Donatienne ; Niccolai, Elena ; Prtenjaca, Nikolina ; Sakowski, Stacey A. ; Bendotti, Caterina ; Mazzini, Letizia
• Description:
  Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease. Despite decades of research and many new insights into disease biology over the 150 years since the disease was first described, causative pathogenic mechanisms in ALS remain poorly understood, especially in sporadic cases. Our understanding of the role of the immune system in ALS pathophysiology, however, is rapidly expanding. The aim of this manuscript is to summarize the recent advances regarding the immune system involvement in ALS, with particular attention to clinical translation. We focus on the potential pathophysiologic mechanism of the immune system in ALS, discussing local and systemic factors (blood, cerebrospinal fluid, and microbiota) that influence ALS onset and progression in animal models and people. We also explore the potential of Positron Emission Tomography to detect neuroinflammation in vivo, and discuss ongoing clinical trials of therapies targeting the immune system. With validation in human patients, new evidence in this emerging field will serve to identify novel therapeutic targets and provide realistic hope for personalized treatment strategies.
• Subjects:
  Amyotrophic Lateral Sclerosis Animals Humans Immune System Neurodegenerative Diseases Positron-Emission Tomography
• Keywords:
  Amyotrophic Lateral Sclerosis Biomarkers Immunity Inflammation Target Targeted Therapies
• Source:
  Neurosci Biobehav Rev. 127:958-978
• Pubmed ID:
  34153344
• Pubmed Central ID:
  PMC8428677
• Document Type:
  Journal Article
• Funding:
  R01 ES030049/ES/NIEHS NIH HHSUnited States/ ; R01 TS000289/TS/ATSDR CDC HHSUnited States/
• Volume:
  127
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:5cfdd98ce8931b2013e69b04ca8c21a9cb3082583a40e3e8df9edf25f5a8a83f9f2d657a99275790614dff3f38f8430b2a4316d5ec3de03c298a55b16c025f09
• Download URL:
  https://stacks.cdc.gov/view/cdc/133283/cdc_133283_DS1.pdf
• File Type:
  [PDF - 1.27 MB ]