Dynamics of protein synthesis in the initial steps of strobilation in the model cestode parasite Mesocestoides corti (syn. vogae)

Details

• Alternative Title:
  J Proteomics
• Personal Author:
  de Lima, Jeferson Camargo ; Floriani, Maiara Anschau ; Debarba, João Antônio ; Paludo, Gabriela Prado ; Monteiro, Karina Mariante ; Moura, Hercules ; Barr, John R. ; Zaha, Arnaldo ; Ferreira, Henrique Bunselmeyer
• Description:
  Biological significance:
  
  Larval cestodiases are life-threatening parasitic diseases that affect both man and domestic animals worldwide. Cestode parasites present complex life cycles, in which they undergo major morphological and physiological changes in the transition from one life-stage to the next. One of these transitions occurs during cestode strobilation, when the mostly undifferentiated and non-segmented larval or pre-adult form develops into a fully segmented and sexually differentiated (strobilated) adult worm. Although the proteomes of bona fide larvae and strobialted adults have been previously characterized for a few cestode species, little is still known about the dynamic of protein synthesis during the early steps of cestode strobilation. Now, the assessment of newly synthesized (NS) proteins within the first 48 h of strobilation the model cestode M. corti allowed to shed light on molecular mechanisms that are triggered by strobilation induction. The functional analyses of this repertoire of over a hundred NS proteins pointed out to changes in metabolism and activation of classical developmental signaling pathways in early strobilation. Many of the identified NS proteins may become valuable cestode developmental markers and their involvement in vital processes make them also good candidate targets for novel anthelmintic drugs.
• Subjects:
  • Animals
  • Cestoda
  • Life Cycle Stages
  • Mesocestoides
  • Parasites
  • Proteome
• Source:
  J Proteomics. 228:103939
• Pubmed ID:
  32798775
• Pubmed Central ID:
  PMC10491476
• Document Type:
  Journal Article
• Funding:
  WT_/Wellcome TrustUnited Kingdom/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  228
• Download URL:
  https://stacks.cdc.gov/view/cdc/132838/cdc_132838_DS1.pdf
• File Type:
  [PDF - 1.37 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8a572feeb7592a6758e544faa3d43c94e91f4887838d78d3c1fe31101031e46f