Vaccine-Associated Paralytic Poliomyelitis: A Review of the Epidemiology and Estimation of the Global Burden

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Platt, Lauren R. ; Estívariz, Concepción F. ; Sutter, Roland W.
• Description:
  Background.
  
  Vaccine-associated paralytic poliomyelitis (VAPP) is a rare adverse event associated with oral poliovirus vaccine (OPV). This review summarizes the epidemiology and provides a global burden estimate.
  
  Methods.
  
  A literature review was conducted to abstract the epidemiology and calculate the risk of VAPP. A bootstrap method was applied to calculate global VAPP burden estimates.
  
  Results.
  
  Trends in VAPP epidemiology varied by country income level. In the low-income country, the majority of cases occurred in individuals who had received >3 doses of OPV (63%), whereas in middle and high-income countries, most cases occurred in recipients after their first OPV dose or unvaccinated contacts (81%). Using all risk estimates, VAPP risk was 4.7 cases per million births (range, 2.4–9.7), leading to a global annual burden estimate of 498 cases (range, 255–1018). If the analysis is limited to estimates from countries that currently use OPV, the VAPP risk is 3.8 cases per million births (range, 2.9–4.7) and a burden of 399 cases (range, 306–490).
  
  Conclusions.
  
  Because many high-income countries have replaced OPV with inactivated poliovirus vaccine, the VAPP burden is concentrated in lower-income countries. The planned universal introduction of inactivated poliovirus vaccine is likely to substantially decrease the global VAPP burden by 80%–90%.
  
  
• Subjects:
  Adolescent Adult Article Child Child, Preschool Developed Countries Developing Countries Female Global Health Humans Inactivated Poliovirus Vaccine (IPV) Infant Infant, Newborn Male OPV Cessation OPV Withdrawal Oral Poliovirus Vaccine (OPV) Polio Endgame Polio Eradication Poliomyelitis Poliovirus Vaccines Prevalence Risk Assessment Vaccine-associated Paralytic Poliomyelitis (VAPP) Young Adult

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• Source:
  J Infect Dis. 210(Suppl 1):S380-S389
• Pubmed ID:
  25316859
• Pubmed Central ID:
  PMC10424844
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  210
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e95caa5669fc8efc7cb940648d720eea05a5740031cf96ea6264607040b18ec2
• Download URL:
  https://stacks.cdc.gov/view/cdc/132036/cdc_132036_DS1.pdf
• File Type:
  [PDF - 451.93 KB ]