Vaccine-Associated Paralytic Poliomyelitis: A Review of the Epidemiology and Estimation of the Global Burden

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Platt, Lauren R. ; Estívariz, Concepción F. ; Sutter, Roland W.
• Description:
  Background.
  
  Vaccine-associated paralytic poliomyelitis (VAPP) is a rare adverse event associated with oral poliovirus vaccine (OPV). This review summarizes the epidemiology and provides a global burden estimate.
  
  Methods.
  
  A literature review was conducted to abstract the epidemiology and calculate the risk of VAPP. A bootstrap method was applied to calculate global VAPP burden estimates.
  
  Results.
  
  Trends in VAPP epidemiology varied by country income level. In the low-income country, the majority of cases occurred in individuals who had received >3 doses of OPV (63%), whereas in middle and high-income countries, most cases occurred in recipients after their first OPV dose or unvaccinated contacts (81%). Using all risk estimates, VAPP risk was 4.7 cases per million births (range, 2.4-9.7), leading to a global annual burden estimate of 498 cases (range, 255-1018). If the analysis is limited to estimates from countries that currently use OPV, the VAPP risk is 3.8 cases per million births (range, 2.9-4.7) and a burden of 399 cases (range, 306-490).
  
  Conclusions.
  
  Because many high-income countries have replaced OPV with inactivated poliovirus vaccine, the VAPP burden is concentrated in lower-income countries. The planned universal introduction of inactivated poliovirus vaccine is likely to substantially decrease the global VAPP burden by 80%-90%.
  
  
• Subjects:
  Adolescent Adult Child Child, Preschool Developed Countries Developing Countries Disease Eradication Female Global Health Humans Infant Infant, Newborn Poliomyelitis

  More +
• Source:
  J Infect Dis. 210(Suppl 1):S380-S389
• Pubmed ID:
  25316859
• Pubmed Central ID:
  PMC10424844
• Document Type:
  Text
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  210
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:d5b3162a48fe723f99eb049c73596c96f68f5a6691bf7ab0a40e1edb26496d87063e5f8b61eb0b8d64504984b7fdd535ba08add45b029863a38e6bdc9eea8398
• Download URL:
  https://stacks.cdc.gov/view/cdc/132036/cdc_132036_DS1.pdf
• File Type:
  [PDF - 451.93 KB ]