Trajectory and Demographic Correlates of Antibodies to SARS-CoV-2 Nucleocapsid in Recently Infected Blood Donors, United States

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Haynes, James M. ; Dodd, Roger Y. ; Crowder, Lauren A. ; Notari, Edward P. ; Stramer, Susan L.
• Description:
  We evaluated antibodies to the nucleocapsid protein of SARS-CoV-2 in a large cohort of blood donors in the United States who were recently infected with the virus. Antibodies to the nucleocapsid protein of SARS-CoV-2 indicate previous infection but are subject to waning, potentially affecting epidemiologic studies. We longitudinally evaluated a cohort of 19,323 blood donors who had evidence of recent infection by using a widely available serologic test to determine the dynamics of such waning. We analyzed overall signal-to-cutoff values for 48,330 donations (average 2.5 donations/person) that had an average observation period of 102 days. The observed peak signal-to-cutoff value varied widely, but the waning rate was consistent across the range, with a half-life of 122 days. Within the cohort, only 0.75% of persons became seronegative. Factors predictive of higher peak values and longer time to seroreversion included increasing age, male sex, higher body mass index, and non-Caucasian race.
• Subjects:
  Antibodies, Viral Blood Donors COVID-19 Demography Humans Male Nucleocapsid Nucleocapsid Proteins SARS-CoV-2 Spike Glycoprotein, Coronavirus
• Source:
  Emerg Infect Dis. 2023; 29(7):1323-1329
• Pubmed ID:
  37163762
• Pubmed Central ID:
  PMC10310359
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  29
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8e4f00e888cbfbc484283161bef3327a957df34711bc208bf31505d29cc2c8eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/130820/cdc_130820_DS1.pdf
• File Type:
  [PDF - 2.22 MB ]