Nationwide Outbreak of Candida auris Infections Driven by COVID-19 Hospitalizations, Israel, 2021–20221

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Biran, Roni ; Cohen, Regev ; Finn, Talya ; Brosh-Nissimov, Tal ; Rahav, Galia ; Yahav, Dafna ; Amit, Sharon ; Shachor-Meyouhas, Yael ; Atamna, Alaa ; Bishara, Jihad ; Ashkenazi-Hoffnung, Liat ; Ben Zvi, Haim ; Hershman-Sarafov, Mirit ; Maayan, Shlomo ; Maor, Yasmin ; Schwartz, Orna ; Zimhony, Oren ; Lellouche, Jonathan ; Elbaz, Meital ; Burdelova, Ela ; Mizrahi, Naama ; Novikov, Anna ; Henig, Oryan ; Ben-Ami, Ronen
• Description:
  We report an outbreak of Candida auris across multiple healthcare facilities in Israel. For the period of May 2014-May 2022, a total of 209 patients with C. auris infection or colonization were identified. The C. auris incidence rate increased 30-fold in 2021 (p = 0.00015), corresponding in time with surges of COVID-19-related hospitalization. Multilocus sequence typing revealed hospital-level outbreaks with distinct clones. A clade III clone, imported into Israel in 2016, accounted for 48.8% of typed isolates after January 2021 and was more frequently resistant to fluconazole (100% vs. 63%; p = 0.00017) and voriconazole (74% vs. 5.2%; p<0.0001) than were non-clade III isolates. A total of 23% of patients had COVID-19, and 78% received mechanical ventilation. At the hospital level, outbreaks initially involved mechanically ventilated patients in specialized COVID-19 units and then spread sequentially to ventilated non-COVID-19 patients and nonventilated patients.
• Subjects:
  Antifungal Agents Candidiasis, Invasive Disease Outbreaks Hospitalization Microbial Sensitivity Tests
• Source:
  Emerg Infect Dis. 2023; 29(7):1302-1311
• Pubmed ID:
  37347492
• Pubmed Central ID:
  PMC10310389
• Document Type:
  Journal Article
• Place as Subject:
  Israel
• Volume:
  29
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:acce74f40c807f696d1f68343911fb2607693c3e1fb00057aec99785257b846b
• Download URL:
  https://stacks.cdc.gov/view/cdc/130808/cdc_130808_DS1.pdf
• File Type:
  [PDF - 3.17 MB ]