Trends in Cirrhosis and Mortality by Age, Sex, Race, and Antiviral Treatment Status Among US Chronic Hepatitis B Patients (2006–2016)

Details

• Alternative Title:
  J Clin Gastroenterol
• Personal Author:
  Lu, Mei ; Li, Jia ; Zhou, Yueren ; Rupp, Loralee B. ; Moorman, Anne C. ; Spradling, Philip R. ; Teshale, Eyasu H. ; Boscarino, Joseph A. ; Daida, Yihe G. ; Schmidt, Mark A. ; Trudeau, Sheri ; Gordon, Stuart C.
• Corporate Authors:
  CHeCS Investigators
• Description:
  Background:
  
  Changing US demographics and evolving chronic hepatitis B (CHB) treatments may affect longitudinal trends in CHB-related complications. We studied trends in the prevalence of cirrhosis (past or present) and incidence of all-cause mortality, stratified by patient age, sex, race, and antiviral treatment status, in a sample from US health care systems.
  
  Methods:
  
  Joinpoint and Poisson regression (univariate and multivariable) were used to estimate the annual percent change in each outcome from 2006 to 2016.
  
  Results:
  
  Among 5528 CHB patients, cirrhosis prevalence (including decompensated cirrhosis) rose from 6.7% in 2006 to 13.7% in 2016; overall mortality was unchanged. Overall rates of cirrhosis and mortality were higher among treated patients, but adjusted annual percent changes (aAPC) were significantly lower among treated than untreated patients (cirrhosis: aAPC +2.4% vs. +6.2%, mortality: aAPC −3.9% vs. +4.0%). Likewise, among treated patients, the aAPC for mortality declined −3.9% per year whereas among untreated patients, mortality increased +4.0% per year.
  
  Conclusions:
  
  From 2006 to 2016, the prevalence of cirrhosis among CHB patients doubled. Notably, all-cause mortality increased among untreated patients but decreased among treated patients. These results suggest that antiviral treatment attenuates the progression of cirrhosis and the risk of death among patients with CHB.
  
  
• Subjects:
  Antiviral Agents Article Carcinoma, Hepatocellular Cirrhosis Prevalence Decompensated Cirrhosis HCC Hepatitis B, Chronic Hepatocellular Carcinoma Humans Incidence Joinpoint Modeling Liver Cirrhosis Liver Neoplasms Liver Transplant Prevalence

  More +
• Source:
  J Clin Gastroenterol. 56(3):273-279
• Pubmed ID:
  33780209
• Pubmed Central ID:
  PMC10257940
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  56
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3faaf003388d70f67f1d0f674f65c476c238138165c90dac7bcebd26d1a16b1e
• Download URL:
  https://stacks.cdc.gov/view/cdc/129851/cdc_129851_DS1.pdf
• File Type:
  [PDF - 689.18 KB ]