Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rodríguez-Grande, Cristina ; Estévez, Agustín ; Palomino-Cabrera, Rosalía ; Molero-Salinas, Andrea ; Peñas-Utrilla, Daniel ; Herranz, Marta ; Sanz-Pérez, Amadeo ; Alcalá, Luis ; Veintimilla, Cristina ; Catalán, Pilar ; Martínez-Laperche, Carolina ; Alonso, Roberto ; Muñoz, Patricia ; Pérez-Lago, Laura ; de Viedma, Darío García
• Corporate Authors:
  on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
• Description:
  Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20-45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated.
• Subjects:
  Coronavirus Coronavirus Disease COVID-19 Early SARS-CoV-2 Reinfections Involving The Same Or Different Genomic Lineages, Spain Genomics Humans Reinfection Research Respiratory Infections Risk Factors SARS SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 Spain United States Viruses Zoonoses

  More +
• Source:
  Emerg Infect Dis. 2023; 29(6):1154-1161
• Pubmed ID:
  37130503
• Pubmed Central ID:
  PMC10202887
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4e868b120a8ad1d0d1d4fca1231442bcdaab72fdb6a45d329fde3bba8d5fe211
• Download URL:
  https://stacks.cdc.gov/view/cdc/129703/cdc_129703_DS1.pdf
• File Type:
  [PDF - 984.78 KB ]