Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hernández, Sergio A. ; Ogrinc, Katarina ; Korva, Miša ; Kastrin, Andrej ; Bogovič, Petra ; Rojko, Tereza ; Kelley, Keith W. ; Weis, Janis J. ; Strle, Franc ; Strle, Klemen
• Description:
  Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and cerebrospinal fluid (CSF) in 79 LNB patients followed for 1 year. At study entry, most mediators were highly concentrated in CSF, the site of the infection. Those responses resolved with antibiotic therapy, and associations between CSF cytokines and signs and symptoms of LNB were no longer observed. In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. Highest IFN-α levels corresponded with severe disease. Although the infection serves as the initial trigger, sequelae after antibiotic therapy are associated with unremitting systemic IFN-α levels, consistent with the pathogenic role of this cytokine in interferonopathies in other conditions.
• Subjects:
  Anti-Bacterial Agents Association Of Persistent Symptoms After Lyme Neuroborreliosis And Increased Levels Of Interferon-α In Blood Blood Bogovič P Cytokines Et Al. Association Of Persistent Symptoms After Lyme Neuroborreliosis And Increased Levels Of Interferon-α In Blood. Emerg Infect Dis. 2023 Jun [date Cited]. Https://doi.org/10.3201/eid2906.221685 Humans IFN-α Immune Response Immunologic Factors Increased Levels Inflammation Interferon-alpha Kastrin A Korva M Lyme Disease Lyme Neuroborreliosis Ogrinc K Persistent Symptoms Post‒Lyme Disease Symptoms Rojko T Slovenia Suggested Citation For This Article: Hernández SA Synopsis Tick-borne Infections United States Vector-borne Infections Zoonoses

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• Source:
  Emerg Infect Dis. 2023; 29(6):1091-1101
• Pubmed ID:
  37209716
• Pubmed Central ID:
  PMC10202885
• Document Type:
  Journal Article
• Funding:
  R21 AI144916/AI/NIAID NIH HHSUnited States/ ; R01 AI150157/AI/NIAID NIH HHSUnited States/ ; K01 AR062098/AR/NIAMS NIH HHSUnited States/ ; R01 AR043521/AR/NIAMS NIH HHSUnited States/
• Volume:
  29
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3edba7151e57a44773c38438b56c7002573141b7c9b45f6532d71415c5662eca
• Download URL:
  https://stacks.cdc.gov/view/cdc/129702/cdc_129702_DS1.pdf
• File Type:
  [PDF - 1.80 MB ]