Similar Prevalence of Plasmodium falciparum and Non–P. falciparum Malaria Infections among Schoolchildren, Tanzania1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sendor, Rachel ; Mitchell, Cedar L. ; Chacky, Frank ; Mohamed, Ally ; Mhamilawa, Lwidiko E. ; Molteni, Fabrizio ; Nyinondi, Ssanyu ; Kabula, Bilali ; Mkali, Humphrey ; Reaves, Erik J. ; Serbantez, Naomi ; Kitojo, Chonge ; Makene, Twilumba ; Kyaw, Thwai ; Muller, Meredith ; Mwanza, Alexis ; Eckert, Erin L. ; Parr, Jonathan B. ; Lin, Jessica T. ; Juliano, Jonathan J. ; Ngasala, Billy
• Description:
  Achieving malaria elimination requires considering both Plasmodium falciparum and non-P. falciparum infections. We determined prevalence and geographic distribution of 4 Plasmodium spp. by performing PCR on dried blood spots collected within 8 regions of Tanzania during 2017. Among 3,456 schoolchildren, 22% had P. falciparum, 24% had P. ovale spp., 4% had P. malariae, and 0.3% had P. vivax infections. Most (91%) schoolchildren with P. ovale infections had low parasite densities; 64% of P. ovale infections were single-species infections, and 35% of those were detected in low malaria endemic regions. P. malariae infections were predominantly (73%) co-infections with P. falciparum. P. vivax was detected mostly in northern and eastern regions. Co-infections with >1 non-P. falciparum species occurred in 43% of P. falciparum infections. A high prevalence of P. ovale infections exists among schoolchildren in Tanzania, underscoring the need for detection and treatment strategies that target non-P. falciparum species.
• Subjects:
  Child Children Coinfection Epidemiology Humans Malaria Malaria, Falciparum Malaria, Vivax Parasites PCR Plasmodium Falciparum Plasmodium Malariae Plasmodium Ovale Plasmodium Vivax Prevalence Research School Survey Similar Prevalence Of Plasmodium Falciparum And Non–P. Falciparum Malaria Infections Among Schoolchildren, Tanzania Tanzania Vector-borne Infections Zoonoses

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• Source:
  Emerg Infect Dis. 2023; 29(6):1143-1153
• Pubmed ID:
  37209670
• Pubmed Central ID:
  PMC10202886
• Document Type:
  Journal Article
• Funding:
  K24 AI134990/AI/NIAID NIH HHSUnited States/ ; R01 TW010870/TW/FIC NIH HHSUnited States/ ; T32 AI070114/AI/NIAID NIH HHSUnited States/ ; R21 AI152260/AI/NIAID NIH HHSUnited States/ ; R21 AI148579/AI/NIAID NIH HHSUnited States/ ; R01 AI139520/AI/NIAID NIH HHSUnited States/ ; T32 AI070114/AI/NIAID NIH HHSUnited States/
• Volume:
  29
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:de570ff382068b4331ea99ee282cd7f5abd0db5c0cae179c3c7492357ee35726
• Download URL:
  https://stacks.cdc.gov/view/cdc/129695/cdc_129695_DS1.pdf
• File Type:
  [PDF - 2.57 MB ]