Evaluation and Management of Congenital Chagas Disease in the United States

Details

• Alternative Title:
  J Pediatric Infect Dis Soc
• Personal Author:
  Edwards, Morven S. ; Stimpert, Kelly K. ; Bialek, Stephanie R. ; Montgomery, Susan P.
• Description:
  Chagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that is transmissible to their offspring. The estimated US maternal-to-infant transmission rate of Trypanosoma cruzi is 1% to 5%. Ten percent to 40% of neonates with congenital T cruzi infection have clinical signs consistent with a congenital infection but no findings are unique to Chagas disease. If left untreated, 20% to 40% of infants with Chagas disease will later develop potentially fatal cardiac manifestations. Molecular testing can confirm the diagnosis in neonates. Treatment is well tolerated in infancy and usually results in cure. Screening of at-risk women during pregnancy can identify maternal infection and allow early assessment and treatment for congenital T cruzi infection.
• Subjects:
  Chagas Disease Female Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical Molecular Diagnostic Techniques Polymerase Chain Reaction Pregnancy Pregnancy Complications, Parasitic Risk Factors Trypanosoma Cruzi United States

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• Keywords:
  Chagas Disease Congenital Infection
• Source:
  J Pediatric Infect Dis Soc. 8(5):461-469
• Pubmed ID:
  31016324
• Pubmed Central ID:
  PMC10186111
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  8
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a62eb10d6c4dd332fc25e8ed29bb107f342e43bd03f79cfc2e2b1f2b366aa13f
• Download URL:
  https://stacks.cdc.gov/view/cdc/128490/cdc_128490_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]