Nasal nitric oxide flux from the paranasal sinuses

Details

• Alternative Title:
  Curr Opin Allergy Clin Immunol
• Personal Author:
  Spector, Barak M. ; Shusterman, Dennis J. ; Zhao, Kai
• Description:
  Purpose of review ; Upper airway nitric oxide (NO) is physiologically important in airway regulation and defense, and can be modulated by various airway inflammatory conditions, including allergic rhinitis and chronic rhinosinusitis – with and without polyposis. Paranasal sinuses serve as a NO reservoir, with concentrations typically exceeding those measured in lower airway (fractional exhaled NO or FeNO) by a few orders of magnitude. However, the dynamics of NO flux between the paranasal sinuses and main nasal airway, which are critical to respiratory NO emission, are poorly understood. ; Recent findings ; Historically, NO emissions were thought to be contributed mostly by the maxillary sinuses (the largest sinuses) and active air movement (convection). However, recent anatomically-accurate computational modeling studies based on patients, CT scans showed that the ethmoid sinuses and diffusive transport dominate the process. ; Summary ; These new findings may have a substantial impact on our view of nasal NO emission mechanisms and sinus physiopathology in general.
• Keywords:
  • computer simulation
  • diffusion
  • human
  • nasal cavity
  • nitric oxide
  • paranasal sinuses
  • Humans
  • Nitric Oxide
  • Nasal Polyps
  • Paranasal Sinuses
  More +
• Source:
  Curr Opin Allergy Clin Immunol. 23(1):22-28
• Pubmed ID:
  36373691
• Pubmed Central ID:
  PMC10170969
• Document Type:
  Journal Article
• Funding:
  R01 DC020302/DC/NIDCD NIH HHSUnited States/ ; T42 OH008429/OH/NIOSH CDC HHSUnited States/
• Volume:
  23
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/128330/cdc_128330_DS1.pdf
• File Type:
  [PDF - 665.92 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4365f9c51e7f32586992dcd818b2c4f60edb3a25a61c429f4615d77ca0bbbf4f