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Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France
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2 2023
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Source: Emerg Infect Dis. 2023; 29(2):286-293
[PDF-2.54 MB]
Details:
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Alternative Title:Emerg Infect Dis
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Description:In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. After ruling out common etiologies, we used metagenomic next-generation sequencing to analyze a liver biopsy sample and identified an unknown species of circovirus, tentatively named human circovirus 1 (HCirV-1). We found no other viral or bacterial sequences. HCirV-1 shared 70% amino acid identity with the closest known viral sequences. The viral genome was undetectable in blood samples from 2017-2019, then became detectable at low levels in September 2020 and peaked at very high titers (10| genome copies/mL) in January 2022. In March 2022, we found >10| genome copies/g or mL in the liver and blood, concomitant with hepatic cytolysis. We detected HCirV-1 transcripts in 2% of hepatocytes, demonstrating viral replication and supporting the role of HCirV-1 in liver damage.
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Pubmed ID:36596569
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Pubmed Central ID:PMC9881760
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Document Type:
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Volume:29
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Issue:2
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