Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pérot, Philippe ; Fourgeaud, Jacques ; Rouzaud, Claire ; Regnault, Béatrice ; Da Rocha, Nicolas ; Fontaine, Hélène ; Le Pavec, Jérôme ; Dolidon, Samuel ; Garzaro, Margaux ; Chrétien, Delphine ; Morcrette, Guillaume ; Molina, Thierry Jo ; Ferroni, Agnès ; Leruez-Ville, Marianne ; Lortholary, Olivier ; Jamet, Anne ; Eloit, Marc
• Description:
  In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. After ruling out common etiologies, we used metagenomic next-generation sequencing to analyze a liver biopsy sample and identified an unknown species of circovirus, tentatively named human circovirus 1 (HCirV-1). We found no other viral or bacterial sequences. HCirV-1 shared 70% amino acid identity with the closest known viral sequences. The viral genome was undetectable in blood samples from 2017-2019, then became detectable at low levels in September 2020 and peaked at very high titers (10| genome copies/mL) in January 2022. In March 2022, we found >10| genome copies/g or mL in the liver and blood, concomitant with hepatic cytolysis. We detected HCirV-1 transcripts in 2% of hepatocytes, demonstrating viral replication and supporting the role of HCirV-1 in liver damage.
• Subjects:
  Circovirus Circoviruses Circovirus Hepatitis Infection In Heart-Lung Transplant Patient, France Female France Genome, Viral Heart-Lung Transplantation Hepatitis Hepatitis A Humans Metagenomic Next-generation Sequencing Middle Aged MNGS Research Solid Organ Transplants Viruses Zoonoses

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• Source:
  Emerg Infect Dis. 2023; 29(2):286-293
• Pubmed ID:
  36596569
• Pubmed Central ID:
  PMC9881760
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a20b5918a769db24b9b53d9388f9696b01eee9af52fd913f6693831725f14d22
• Download URL:
  https://stacks.cdc.gov/view/cdc/127674/cdc_127674_DS1.pdf
• File Type:
  [PDF - 2.54 MB ]