Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Khoury, David S. ; Schlub, Timothy E. ; Cromer, Deborah ; Steain, Megan ; Fong, Youyi ; Gilbert, Peter B. ; Subbarao, Kanta ; Triccas, James A. ; Kent, Stephen J. ; Davenport, Miles P.
• Description:
  Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic.
• Subjects:
  2019 Novel Coronavirus Disease Antibodies, Neutralizing Antibodies, Viral Coronavirus Disease Correlates Of Protection Correlates Of Protection, Thresholds Of Protection, And Immunobridging Among Persons With SARS-CoV-2 Infection COVID-19 COVID-19 Vaccines Humans Neutralizing Antibody Pandemics Research Respiratory Infections SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein, Coronavirus Standardization Vaccine Efficacy Viruses Zoonoses

  More +
• Source:
  Emerg Infect Dis. 2023; 29(2):381-388
• Pubmed ID:
  36692375
• Pubmed Central ID:
  PMC9881762
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ac1b241a4a6f62a733aff48685cafd1358e609a23d20ac58f8d954118322a104
• Download URL:
  https://stacks.cdc.gov/view/cdc/127667/cdc_127667_DS1.pdf
• File Type:
  [PDF - 1.86 MB ]