Clonal Dissemination of Antifungal-Resistant Candida haemulonii, China

Chen, Xinfei; Jia, Xinmiao; Bing, Jian; Zhang, Han; Hong, Nan; Liu, Yun; Xi, Haiyang; Wang, Weiping; Liu, Zhiyong; Zhang, Qiangqiang; Li, Li; Kang, Mei; Xiao, Yuling; Yang, Bin; Lin, Yulan; Xu, Hui; Fan, Xin; Huang, Jingjing; Gong, Jie; Xu, Juan; Xie, Xiuli; Yang, Wenhang; Zhang, Ge; Zhang, Jingjia; Kang, Wei; Wang, He; Hou, Xin; Xiao, Meng; Xu, Yingchun

doi:10.3201/eid2903.221082

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Clonal Dissemination of Antifungal-Resistant Candida haemulonii, China

3 2023
By Chen, Xinfei ; Jia, Xinmiao ; Bing, Jian ; ...
http://dx.doi.org/10.3201/eid2903.221082
Source: Emerg Infect Dis. 2023; 29(3):576-584

[PDF-3.25 MB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Chen, Xinfei ; Jia, Xinmiao ; Bing, Jian ; Zhang, Han ; Hong, Nan ; ... More +

Chen, Xinfei ; Jia, Xinmiao ; Bing, Jian ; Zhang, Han ; Hong, Nan ; Liu, Yun ; Xi, Haiyang ; Wang, Weiping ; Liu, Zhiyong ; Zhang, Qiangqiang ; Li, Li ; Kang, Mei ; Xiao, Yuling ; Yang, Bin ; Lin, Yulan ; Xu, Hui ; Fan, Xin ; Huang, Jingjing ; Gong, Jie ; Xu, Juan ; Xie, Xiuli ; Yang, Wenhang ; Zhang, Ge ; Zhang, Jingjia ; Kang, Wei ; Wang, He ; Hou, Xin ; Xiao, Meng ; Xu, Yingchun Less -
Description:

Candida haemulonii, a relative of C. auris, frequently shows antifungal resistance and is transmissible. However, molecular tools for genotyping and investigating outbreaks are not yet established. We performed genome-based population analysis on 94 C. haemulonii strains, including 58 isolates from China and 36 other published strains. Phylogenetic analysis revealed that C. haemulonii can be divided into 4 clades. Clade 1 comprised strains from China and other global strains; clades 2-4 contained only isolates from China, were more recently evolved, and showed higher antifungal resistance. Four regional epidemic clusters (A, B, C, and D) were identified in China, each comprising ≥5 cases (largest intracluster pairwise single-nucleotide polymorphism differences <50 bp). Cluster A was identified in 2 hospitals located in the same city, suggesting potential intracity transmissions. Cluster D was resistant to 3 classes of antifungals. The emergence of more resistant phylogenetic clades and regional dissemination of antifungal-resistant C. haemulonii warrants further monitoring.
Subjects:

[+]

Antifungal Agents Candida Candidiasis Clone Cells Drug Resistance, Fungal Microbial Sensitivity Tests Phylogeny
Source:

Emerg Infect Dis. 2023; 29(3):576-584
Pubmed ID:

36823029
Pubmed Central ID:

PMC9973686
Document Type:

Journal Article
Place as Subject:

China
Volume:

29
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:bb163ef83fd14f81dd79a5b39df55d62e991b2d4f00b298a90eabf5d86c871e6
Download URL:

https://stacks.cdc.gov/view/cdc/127644/cdc_127644_DS1.pdf
File Type:

	22-1082.nxml	xml
	22-1082-F1.gif	gif
	22-1082-F1.jpg	jpeg
	22-1082-F2.gif	gif
	22-1082-F2.jpg	jpeg
	22-1082-F3.gif	gif
	22-1082-F3.jpg	jpeg
	22-1082-Techapp-s1.xlsx	xlsx
	22-1082-Techapp-s2.pdf	pdf

More +