Multicenter Case–Control Study of COVID-19–Associated Mucormycosis Outbreak, India

Muthu, Valliappan; Agarwal, Ritesh; Rudramurthy, Shivaprakash Mandya; Thangaraju, Deepak; Shevkani, Manoj Radhakishan; Patel, Atul K.; Shastri, Prakash Srinivas; Tayade, Ashwini; Bhandari, Sudhir; Gella, Vishwanath; Savio, Jayanthi; Madan, Surabhi; Hallur, Vinay Kumar; Maturu, Venkata Nagarjuna; Srinivasan, Arjun; Sethuraman, Nandini; Sibia, Raminder Pal Singh; Pujari, Sanjay; Mehta, Ravindra; Singhal, Tanu; Saxena, Puneet; Gupta, Varsha; Nagvekar, Vasant; Prayag, Parikshit; Patel, Dharmesh; Xess, Immaculata; Savaj, Pratik; Panda, Naresh; Rajagopal, Gayathri Devi; Parwani, Riya Sandeep; Patel, Kamlesh; Deshmukh, Anuradha; Vyas, Aruna; Sistla, Srinivas Kishore; Padaki, Priyadarshini A; Ramar, Dharshni; Sarkar, Saurav; Rachagulla, Bharani; Vallandaramam, Pattabhiraman; Premachandran, Krishna Prabha; Pawar, Sunil; Gugale, Piyush; Hosamani, Pradeep; Dutt, Sunil Narayan; Nair, Satish; Kalpakkam, Hariprasad; Badhwar, Sanjiv; Kompella, Kiran Kumar; Singla, Nidhi; Navlakhe, Milind; Prayag, Amrita; Singh, Gagandeep; Dhakecha, Poorvesh; Chakrabarti, Arunaloke

doi:10.3201/eid2901.220926

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Multicenter Case–Control Study of COVID-19–Associated Mucormycosis Outbreak, India

1 2023
By Muthu, Valliappan ; Agarwal, Ritesh ; Rudramurthy, Shivaprakash Mandya ; ...
http://dx.doi.org/10.3201/eid2901.220926
Source: Emerg Infect Dis. 2023; 29(1):8-19

[PDF-1.66 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Muthu, Valliappan ; Agarwal, Ritesh ; Rudramurthy, Shivaprakash Mandya ; Thangaraju, Deepak ; Shevkani, Manoj Radhakishan ; ... More +

Muthu, Valliappan ; Agarwal, Ritesh ; Rudramurthy, Shivaprakash Mandya ; Thangaraju, Deepak ; Shevkani, Manoj Radhakishan ; Patel, Atul K. ; Shastri, Prakash Srinivas ; Tayade, Ashwini ; Bhandari, Sudhir ; Gella, Vishwanath ; Savio, Jayanthi ; Madan, Surabhi ; Hallur, Vinay Kumar ; Maturu, Venkata Nagarjuna ; Srinivasan, Arjun ; Sethuraman, Nandini ; Sibia, Raminder Pal Singh ; Pujari, Sanjay ; Mehta, Ravindra ; Singhal, Tanu ; Saxena, Puneet ; Gupta, Varsha ; Nagvekar, Vasant ; Prayag, Parikshit ; Patel, Dharmesh ; Xess, Immaculata ; Savaj, Pratik ; Panda, Naresh ; Rajagopal, Gayathri Devi ; Parwani, Riya Sandeep ; Patel, Kamlesh ; Deshmukh, Anuradha ; Vyas, Aruna ; Sistla, Srinivas Kishore ; Padaki, Priyadarshini A ; Ramar, Dharshni ; Sarkar, Saurav ; Rachagulla, Bharani ; Vallandaramam, Pattabhiraman ; Premachandran, Krishna Prabha ; Pawar, Sunil ; Gugale, Piyush ; Hosamani, Pradeep ; Dutt, Sunil Narayan ; Nair, Satish ; Kalpakkam, Hariprasad ; Badhwar, Sanjiv ; Kompella, Kiran Kumar ; Singla, Nidhi ; Navlakhe, Milind ; Prayag, Amrita ; Singh, Gagandeep ; Dhakecha, Poorvesh ; Chakrabarti, Arunaloke Less -
Description:

We performed a case–control study across 25 hospitals in India for the period of January–June 2021 to evaluate the reasons for an COVID-19–associated mucormycosis (CAM) outbreak. We investigated whether COVID-19 treatment practices (glucocorticoids, zinc, tocilizumab, and others) were associated with CAM. We included 1,733 cases of CAM and 3,911 age-matched COVID-19 controls. We found cumulative glucocorticoid dose (odds ratio [OR] 1.006, 95% CI 1.004–1.007) and zinc supplementation (OR 2.76, 95% CI 2.24–3.40), along with elevated C-reactive protein (OR 1.004, 95% CI 1.002–1.006), host factors (renal transplantation [OR 7.58, 95% CI 3.31–17.40], diabetes mellitus [OR 6.72, 95% CI 5.45–8.28], diabetic ketoacidosis during COVID-19 [OR 4.41, 95% CI 2.03–9.60]), and rural residence (OR 2.88, 95% CI 2.12–3.79), significantly associated with CAM. Mortality rate at 12 weeks was 32.2% (473/1,471). We emphasize the judicious use of COVID-19 therapies and optimal glycemic control to prevent CAM.
Subjects:

[+]

Case-Control Studies COVID-19 Humans Mucorales Mucormycosis Multicenter Studies As Topic
Source:

Emerg Infect Dis. 2023; 29(1):8-19
Pubmed ID:

36573628
Pubmed Central ID:

PMC9796192
Document Type:

Journal Article
Place as Subject:

India
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:bd7d63ea0cc38dca4ec5dfd83d2ea0d1ae459a5dfe0c849d7bb0d75812257c4d
Download URL:

https://stacks.cdc.gov/view/cdc/127632/cdc_127632_DS1.pdf
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