Genomic Epidemiology Linking Nonendemic Coccidioidomycosis to Travel

Monroy-Nieto, Juan; Gade, Lalitha; Benedict, Kaitlin; Etienne, Kizee A.; Litvintseva, Anastasia P.; Bowers, Jolene R.; Engelthaler, David M.; Chow, Nancy A.

doi:10.3201/eid2901.220771

i

Genomic Epidemiology Linking Nonendemic Coccidioidomycosis to Travel

Supporting Files Public Domain

1 2023
By Monroy-Nieto, Juan ; Gade, Lalitha ; Benedict, Kaitlin ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Monroy-Nieto, Juan ; Gade, Lalitha ; Benedict, Kaitlin ; Etienne, Kizee A. ; Litvintseva, Anastasia P. ; Bowers, Jolene R. ; Engelthaler, David M. ; Chow, Nancy A.
Description:

Coccidioidomycosis is a fungal infection endemic to hot, arid regions of the western United States, northern Mexico, and parts of Central and South America. Sporadic cases outside these regions are likely travel-associated; alternatively, an infection could be acquired in as-yet unidentified newly endemic locales. A previous study of cases in nonendemic regions with patient self-reported travel history suggested that infections were acquired during travel to endemic regions. We sequenced 19 Coccidioides isolates from patients with known travel histories from that earlier investigation and performed phylogenetic analysis to identify the locations of potential source populations. Our results show that those isolates were phylogenetically linked to Coccidioides subpopulations naturally occurring in 1 of the reported travel locales, confirming that these cases were likely acquired during travel to endemic regions. Our findings demonstrate that genomic analysis is a useful tool for investigating travel-related coccidioidomycosis.
Subjects:

Airborne Infections Coccidioides Coccidioides Phylogeography Coccidioidomycosis Epidemiology Fungi Genomic Epidemiology Linking Nonendemic Coccidioidomycosis To Travel Genomics Humans Phylogeny Research Respiratory Infections Travel Travel-related Illness United States Whole-genome Sequencing
Source:

Emerg Infect Dis. 2023; 29(1):110-117
Pubmed ID:

36573555
Pubmed Central ID:

PMC9796224
Document Type:

Journal Article
Volume:

29
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2e40dd0cae8875f71e20046f23d5b1592e93db0fe7a51654fd04decdf11adc53
Download URL:

https://stacks.cdc.gov/view/cdc/127625/cdc_127625_DS1.pdf
File Type:

[PDF - 3.11 MB ]

File Language:

English

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