Prevalence and Impact of Chagas Disease Among Latin American Immigrants With Nonischemic Cardiomyopathy in Los Angeles, California

Details

• Alternative Title:
  Circ Heart Fail
• Personal Author:
  Traina, Mahmoud I. ; Sanchez, Daniel R. ; Hernandez, Salvador ; Bradfield, Jason S. ; Labedi, Mohamed R. ; Ngab, Tarik A. ; Steurer, Frank ; Montgomery, Susan P. ; Meymandi, Sheba K.
• Description:
  Background
  
  Chagas disease is a well-known cause of cardiomyopathy in Latin America; however, 300 000 individuals are estimated to have Chagas disease in the United States. This study examined the prevalence and impact of Chagas cardiomyopathy (CCM) in a US population. We hypothesized that patients with CCM would have increased morbidity and mortality when compared with patients with non-CCM.
  
  Methods and Results
  
  This is a single-center, prospective cohort study. Enrollment criteria were new diagnosis of nonischemic cardiomyopathy (left ventricular ejection fraction ≤40%) and previous residence in Latin America for at least 12 months. Serological testing for Trypanosoma cruzi was performed at enrollment. The primary end point was all-cause mortality or heart transplantation. The secondary end point was heart failure–related hospitalization. A total of 135 patients were enrolled, with a median of 43 months of follow-up. Chagas disease was diagnosed in 25 (19%) patients. The primary end point occurred in 9 patients (36%) in the CCM group and in 11 patients (10%) in the non-CCM group (hazard ratio [HR], 4.46; 95% confidence interval, 1.8–10.8; P=0.001). The secondary end point occurred in 13 patients (52%) in the CCM group and in 35 patients (32%) in the non-CCM group (HR, 2.22; 95% confidence interval, 1.2–4.2; P=0.01).
  
  Conclusions
  
  There is a high prevalence of Chagas disease among Latin American immigrants diagnosed with nonischemic cardiomyopathy in Los Angeles. Advanced CCM portends a poor prognosis and is associated with increased all-cause mortality/heart transplantation and heart failure–related hospitalization.
  
  
• Subjects:
  Aged Cardiomyopathies Chagas Disease Emigrants And Immigrants Female Follow-Up Studies Humans Male Middle Aged Prevalence Prospective Studies

  More +
• Source:
  Circ Heart Fail. 8(5):938-943
• Pubmed ID:
  26206855
• Pubmed Central ID:
  PMC10108371
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  California ; Latin America
• Volume:
  8
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1f8c131e5495f925676514dd35ff20c9276f07b802ece6dbbaa3127f3ed183e5
• Download URL:
  https://stacks.cdc.gov/view/cdc/127268/cdc_127268_DS1.pdf
• File Type:
  [PDF - 462.43 KB ]