Amyotrophic lateral sclerosis

Details

• Alternative Title:
  Lancet
• Personal Author:
  Feldman, Eva L ; Goutman, Stephen A ; Petri, Susanne ; Mazzini, Letizia ; Savelieff, Masha G ; Shaw, Pamela J ; Sobue, Gen
• Description:
  Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive research, current management of amyotrophic lateral sclerosis remains suboptimal from diagnosis to prognosis. Recognition of the phenotypic heterogeneity of amyotrophic lateral sclerosis, global CNS dysfunction, genetic architecture, and development of novel diagnostic criteria is clarifying the spectrum of clinical presentation and facilitating diagnosis. Insights into the pathophysiology of amyotrophic lateral sclerosis, identification of disease biomarkers and modifiable risks, along with new predictive models, scales, and scoring systems, and a clinical trial pipeline of mechanism-based therapies, are changing the prognostic landscape. Although most recent advances have yet to translate into patient benefit, the idea of amyotrophic lateral sclerosis as a complex syndrome is already having tangible effects in the clinic. This Seminar will outline these insights and discuss the status of the management of amyotrophic lateral sclerosis for the general neurologist, along with future prospects that could improve care and outcomes for patients with amyotrophic lateral sclerosis.
• Keywords:
  Amyotrophic Lateral Sclerosis Biomarker Biomarkers Clinical Overlap Diagnosis Epidemiology Exposome Forecasting Genetic Architecture Humans Motor Neuron Disease Neurodegenerative Diseases Pathophysiology Phenotype Prognosis Scoring Staging

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• Source:
  Lancet. 400(10360):1363-1380
• Pubmed ID:
  36116464
• Pubmed Central ID:
  PMC10089700
• Document Type:
  Journal Article
• Funding:
  R01 TS000289/TS/ATSDR CDC HHSUnited States/ ; R01TS000289/ACL/ACL HHSUnited States/ ; R01 TS000327/TS/ATSDR CDC HHSUnited States/ ; K23 ES027221/ES/NIEHS NIH HHSUnited States/ ; R01 ES030049/ES/NIEHS NIH HHSUnited States/ ; R01 NS120926/NS/NINDS NIH HHSUnited States/ ; R01 NS127188/NS/NINDS NIH HHSUnited States/
• Volume:
  400
• Issue:
  10360
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d8deba7def3e2ea9f10d6fe1226aaf47281c2a11967f5078215c32c3d2e99c97
• Download URL:
  https://stacks.cdc.gov/view/cdc/126894/cdc_126894_DS1.pdf
• File Type:
  [PDF - 1.58 MB ]