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Supplementary Material for: Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes
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2017
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Details:
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Alternative Title:figshare Academic Research System
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Journal Article:Hormone Research in Paediatrics
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Personal Author:
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Corporate Authors:Ambry Genetics ; Colorado School of Public Health, University of Colorado Denver ; Core for Biomedical Statistics, Center for Clinical and Translational Research, Seattle Children's Research Institute ; Department of Biostatistics and Data Science, Wake Forest School of Medicine ; Department of Biostatistics and School of Nursing, University of North Carolina at Chapel Hill ; ... More +
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Description:Background/Aims: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. Methods: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6–19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes. Results: Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses. Conclusion: We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.
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Content Notes:Stacks:47730
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Modified:05/29/2017
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Date Issued:01/01/2017
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Funding:Centers for Disease Control and Prevention(100000030:SCIVAL;) ; National Center for Advancing Translational Sciences(UL1TR002319:NA;UL1TR001450:NA;UL1TR000423:NA;UL1TR000154:NA;UL1TR001425:NA;100006108:SCIVAL;) ; National Center for Research Resources(M01RR000069:NA;M01RR000037:NA;100000097:SCIVAL;UL1RR026314:NA;UL1RR029882:NA;) ; National Institute of Diabetes and Digestive and Kidney Diseases(P30DK057516:NA;R01DK077949:NA;K23DK089017:NA;UC4DK108173:NA;100000062:SCIVAL;K23DK093804:NA;P30DK056350:NA;) ; National Institutes of Health(100000002:SCIVAL;)
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