Association of urinary biomarkers of smoking-related toxicants with lung cancer incidence in smokers: The Multiethnic Cohort Study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Cigan, Shannon S. ; Murphy, Sharon E. ; Stram, Daniel O. ; Hecht, Stephen S. ; Le Marchand, Loïc ; Stepanov, Irina ; Park, Sungshim L.
• Description:
  Background:
  
  While cigarette smoking is the leading cause of lung cancer, the majority of smokers do not develop the disease over their lifetime. The inter-individual differences in risk among smokers may in part be due to variations in exposure to smoking-related toxicants.
  
  Methods:
  
  Using data from a subcohort of 2,309 current smokers at the time of urine collection from the Multiethnic Cohort Study, we prospectively evaluated the association of ten urinary biomarkers of smoking-related toxicants (total nicotine equivalents [TNE], a ratio of total trans-3’-hydroxycotinine [3-HCOT]/cotinine [a phenotypic measure of CYP2A6 enzymatic activity], 4-(methylnitrosamino)-1–3-(pyridyl)-1-butanol [NNAL], S-phenylmercapturic acid [SPMA], 3-hydroxypropyl mercapturic acid [3-HPMA], phenanthrene tetraol [PheT], 3-hydroxyphenanthrene [PheOH], the ratio of PheT/PheOH, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid [8-iso-PGF2α]) with lung cancer risk (n=140 incident lung cancer cases over an average of 13.4 years of follow-up). Lung cancer risk was estimated using Cox proportional hazards models.
  
  Results:
  
  After adjusting for decade of birth, sex, race/ethnicity, body mass index, self-reported pack-years, creatinine, and urinary TNE (a biomarker of internal smoking dose), a one standard deviation increase in log total 3-HCOT/cotinine (HR=1.33, 95% CI:1.06–1.66), 3-HPMA (HR=1.41, 95% CI:1.07–1.85), and Cd (HR=1.45, 95% CI: 1.18–1.79) were each associated with increased lung cancer risk.
  
  Conclusion:
  
  Our study demonstrates that urinary total 3-HCOT/cotinine, 3-HPMA, and Cd are positively associated with lung cancer risk. These findings warrant replication and consideration as potential biomarkers for smoking-related lung cancer risk.
  
  Impact:
  
  These biomarkers may provide additional information on lung cancer risk that is not captured by self-reported smoking history or TNE.
  
  
• Subjects:
  Biomarkers Cadmium Cigarette Smoking Cohort Studies Cotinine Humans Incidence Lung Neoplasms Nitrosamines Smokers
• Keywords:
  Lung Cancer Smoking Smoking-related Biomarkers
• Source:
  Cancer Epidemiol Biomarkers Prev. 32(3):306-314
• Pubmed ID:
  36350738
• Pubmed Central ID:
  PMC9992134
• Document Type:
  Journal Article
• Funding:
  P01 CA138338/CA/NCI NIH HHSUnited States/ ; P30 CA071789/CA/NCI NIH HHSUnited States/ ; U01 CA164973/CA/NCI NIH HHSUnited States/ ; R01 CA179246/CA/NCI NIH HHSUnited States/ ; T42 OH008434/OH/NIOSH CDC HHSUnited States/
• Volume:
  32
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c87c4f516f1a6c05dd84a9661e94c265b20d162d8d5d20f3ddcc366dd77d2632caf04c29ef24bdce2db23c356fe9cf1bb7bb9ecac5b1af281eafc5f73ab9cbf9
• Download URL:
  https://stacks.cdc.gov/view/cdc/125645/cdc_125645_DS1.pdf
• File Type:
  [PDF - 384.38 KB ]