Effectiveness of Whole-Virus COVID-19 Vaccine among Healthcare Personnel, Lima, Peru

Arriola, Carmen S.; Soto, Giselle; Westercamp, Matthew; Bollinger, Susan; Espinoza, Angelica; Grogl, Max; Llanos-Cuentas, Alejandro; Matos, Eduardo; Romero, Candice; Silva, Maria; Smith, Rachel; Olson, Natalie; Prouty, Michael; Azziz-Baumgartner, Eduardo; Lessa, Fernanda C.

doi:10.3201/eid2813.212477

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Effectiveness of Whole-Virus COVID-19 Vaccine among Healthcare Personnel, Lima, Peru

12 2022
By Arriola, Carmen S. ; Soto, Giselle ; Westercamp, Matthew ; ...
http://dx.doi.org/10.3201/eid2813.212477
Source: Emerg Infect Dis. 2022; 28(Suppl 1):S238-S243

[PDF-666.07 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Arriola, Carmen S. ; Soto, Giselle ; Westercamp, Matthew ; Bollinger, Susan ; Espinoza, Angelica ; ... More +

Arriola, Carmen S. ; Soto, Giselle ; Westercamp, Matthew ; Bollinger, Susan ; Espinoza, Angelica ; Grogl, Max ; Llanos-Cuentas, Alejandro ; Matos, Eduardo ; Romero, Candice ; Silva, Maria ; Smith, Rachel ; Olson, Natalie ; Prouty, Michael ; Azziz-Baumgartner, Eduardo ; Lessa, Fernanda C. Less -
Description:

In February 2021, Peru launched a COVID-19 vaccination campaign among healthcare personnel using an inactivated whole-virus vaccine. The manufacturer recommended 2 vaccine doses 21 days apart. We evaluated vaccine effectiveness among an existing multiyear influenza vaccine cohort at 2 hospitals in Lima. We analyzed data on 290 participants followed during February-May 2021. Participants completed a baseline questionnaire and provided weekly self-collected nasal swab samples; samples were tested by real-time reverse transcription PCR. Median participant follow-up was 2 (range 1-11) weeks. We performed multivariable logistic regression and adjusted for preselected characteristics. During the study, 25 (9%) participants tested SARS-CoV-2-positive. We estimated adjusted vaccine effectiveness at 95% (95% CI 70%-99%) among fully vaccinated participants and 100% (95% CI 88%-100%) among partially vaccinated participants. These data can inform the use and acceptance of inactivated whole-virus vaccine and support vaccination efforts in the region.
Subjects:

[+]

COVID-19 Vaccines COVID-19/epidemiology COVID-19/prevention & Control Delivery Of Health Care Health Personnel Humans SARS-COV-2 Vaccination
Source:

Emerg Infect Dis. 2022; 28(Suppl 1):S238-S243
Pubmed ID:

36502444
Pubmed Central ID:

PMC9745240
Document Type:

Journal Article
Place as Subject:

Peru
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:7f345e1119546f6933f68d9d5bb82b8ab13e41e68fd23a34b24220272070964d
Download URL:

https://stacks.cdc.gov/view/cdc/123287/cdc_123287_DS1.pdf
File Type:

21-2477.nxml

xml

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