Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses

Wang, Lu; Tracy, Lauren; Su, Weijia; Yang, Fu; Feng, Yu; Silverman, Neal; Zhang, ZZ Zhao

doi:10.1038/s41588-022-01214-9

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Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses

12 2022
By Wang, Lu ; Tracy, Lauren ; Su, Weijia ; ...
http://dx.doi.org/10.1038/s41588-022-01214-9
Source: Nat Genet. 54(12):1933-1945

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Alternative Title:

Nat Genet
Personal Author:

Wang, Lu ; Tracy, Lauren ; Su, Weijia ; Yang, Fu ; Feng, Yu ; ... More +

Wang, Lu ; Tracy, Lauren ; Su, Weijia ; Yang, Fu ; Feng, Yu ; Silverman, Neal ; Zhang, ZZ Zhao Less -
Description:

Retrotransposons are one type of mobile genetic element that abundantly reside in the genomes of nearly all animals. Their uncontrolled activation is linked to sterility, cancer and other pathologies, thereby being largely considered detrimental. Here we report that, within a specific time window of development, retrotransposon activation can license the host's immune system for future antiviral responses. We found that the mdg4 (also known as Gypsy) retrotransposon selectively becomes active during metamorphosis at the Drosophila pupal stage. At this stage, mdg4 activation educates the host's innate immune system by inducing the systemic antiviral function of the nuclear factor-κB protein Relish in a dSTING-dependent manner. Consequently, adult flies with mdg4, Relish or dSTING silenced at the pupal stage are unable to clear exogenous viruses and succumb to viral infection. Altogether, our data reveal that hosts can establish a protective antiviral response that endows a long-term benefit in pathogen warfare due to the developmental activation of mobile genetic elements.
Subjects:

[+]

Animals Article Drosophila Retroelements
Source:

Nat Genet. 54(12):1933-1945
Pubmed ID:

36396707
Pubmed Central ID:

PMC9795486
Document Type:

Journal Article
Funding:

DP5 OD021355/OD/NIH HHSUnited States/ ; R01 GM141018/GM/NIGMS NIH HHSUnited States/ ; R01 GM141018/GM/NIGMS NIH HHSUnited States/ ; DP5 OD021355/CD/ODCDC CDC HHSUnited States/

DP5 OD021355/OD/NIH HHSUnited States/ ; R01 GM141018/GM/NIGMS NIH HHSUnited States/ ; R01 GM141018/GM/NIGMS NIH HHSUnited States/ ; DP5 OD021355/CD/ODCDC CDC HHSUnited States/ Less -
Volume:

54
Issue:

12
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:6531e43006ee171df5b57d8f22926751420ae6b5f2ae13d01dfb1302a998d011
Download URL:

https://stacks.cdc.gov/view/cdc/123080/cdc_123080_DS1.pdf
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