World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation

Huang, Chuan; Kritikos, Minos; Sosa, Mario Serrano; Hagan, Thomas; Domkan, Alan; Meliker, Jaymie; Pellecchia, Alison C.; Santiago-Michels, Stephanie; Carr, Melissa A.; Kotov, Roman; Horton, Megan; Gandy, Sam; Sano, Mary; Bromet, Evelyn J.; Lucchini, Roberto G.; Clouston, Sean A. P.; Luft, Benjamin J.

doi:10.1007/s12035-022-03059-z

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World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation

2023
By Huang, Chuan ; Kritikos, Minos ; Sosa, Mario Serrano ; ...
http://dx.doi.org/10.1007/s12035-022-03059-z
Source: Mol Neurobiol. 60(1):160-170

[PDF-938.13 KB]

English

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Details:

Alternative Title:

Mol Neurobiol
Personal Author:

Huang, Chuan ; Kritikos, Minos ; Sosa, Mario Serrano ; Hagan, Thomas ; Domkan, Alan ; ... More +

Huang, Chuan ; Kritikos, Minos ; Sosa, Mario Serrano ; Hagan, Thomas ; Domkan, Alan ; Meliker, Jaymie ; Pellecchia, Alison C. ; Santiago-Michels, Stephanie ; Carr, Melissa A. ; Kotov, Roman ; Horton, Megan ; Gandy, Sam ; Sano, Mary ; Bromet, Evelyn J. ; Lucchini, Roberto G. ; Clouston, Sean A. P. ; Luft, Benjamin J. Less -
Description:

Responders to the World Trade Center (WTC) attacks on 9/11/2001 inhaled toxic dust and experienced severe trauma for a prolonged period. Studies report that WTC site exposure duration is associated with peripheral inflammation and risk for developing early-onset dementia (EOD). Free Water Fraction (FWF) can serve as a biomarker for neuroinflammation by measuring in vivo movement of free water across neurons. The present case-controlled study aimed to examine associations between WTC site exposure duration as well as EOD status with increased hippocampal and cerebral neuroinflammation. Ninety-nine WTC responders (mean age of 56) were recruited between 2017 and 2019 (N = 48 with EOD and 51 cognitively unimpaired). Participants were matched on age, sex, occupation, race, education, and post-traumatic stress disorder (PTSD) status. Participants underwent neuroimaging using diffusion tensor imaging protocols for FWF extraction. Region of interest (ROI) analysis and correlational tractography explored topographical distributions of FWF associations. Apolipoprotein-e4 allele (APOEε4) status was available for most responders (N = 91). Hippocampal FWF was significantly associated with WTC site exposure duration (r = 0.30, p = 0.003), as was cerebral white matter FWF (r = 0.20, p = 0.044). ROI analysis and correlational tractography identified regions within the limbic, frontal, and temporal lobes. Hippocampal FWF and its association with WTC exposure duration were highest when the APOEε4 allele was present (r = 0.48, p = 0.039). Our findings demonstrate that prolonged WTC site exposure is associated with increased hippocampal and cerebral white matter neuroinflammation in WTC responders, possibly exacerbated by possession of the APOEε4 allele.
Subjects:

[+]

Diffusion Tensor Imaging Hippocampus Humans Middle Aged Neuroinflammatory Diseases September 11 Terrorist Attacks Water White Matter
Source:

Mol Neurobiol. 60(1):160-170
Pubmed ID:

36242735
Pubmed Central ID:

PMC9758101
Document Type:

Journal Article
Funding:

R01 AG049953/AG/NIA NIH HHSUnited States/ ; U01 OH011314/OH/NIOSH CDC HHSUnited States/ ; NIH/NIA R01 AG049953/AG/NIA NIH HHSUnited States/ ; U01OH011314/CC/CDC HHSUnited States/

R01 AG049953/AG/NIA NIH HHSUnited States/ ; U01 OH011314/OH/NIOSH CDC HHSUnited States/ ; NIH/NIA R01 AG049953/AG/NIA NIH HHSUnited States/ ; U01OH011314/CC/CDC HHSUnited States/ Less -
Volume:

60
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:26f4b6350dc4b1093295078d2df9264800034cde77d3408a7a55a6c3c945f9ed
Download URL:

https://stacks.cdc.gov/view/cdc/122916/cdc_122916_DS1.pdf
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