Longitudinal Changes in Diffusion Tensor Imaging in Hemodialysis Patients

Details

• Alternative Title:
  Hemodial Int
• Personal Author:
  Richerson, Wesley T ; Schmit, Brian D ; Wolfgram, Dawn F
• Description:
  Introduction:
  
  Hemodialysis patients have increased white matter and gray matter pathology in the brain relative to controls based on MRI. Diffusion tensor imaging is useful in detecting differences between hemodialysis and controls but has not identified the expected longitudinal decline in hemodialysis patients. In this study we implemented specialized post processing techniques to reduce noise to detect longitudinal changes in diffusion tensor imaging parameters and evaluated for any association with changes in cognition.
  
  Methods:
  
  We collected anatomical and diffusion MRIs as well as cognitive testing from in-center hemodialysis patients at baseline and one year later. Gray matter thickness, white matter volume, and white matter diffusion tensor imaging parameters were measured to identify longitudinal changes. We analyzed the diffusion tensor imaging parameters by averaging the whole white matter and using a pothole analysis. 18 hemodialysis patients were included in the longitudinal analysis and 15 controls were used for the pothole analysis. We used the NIH Toolbox Cognition Battery to assess cognitive performance over the same time frame.
  
  Findings:
  
  Over the course of a year on hemodialysis, we found a decrease in white matter fractional anisotropy across the entire white matter (p < 0.01), and an increase in the number of white matter fractional anisotropy voxels below pothole threshold (p = 0.03). We did not find any relationship between changes in whole brain structural parameters and cognitive performance.
  
  Discussion:
  
  By employing noise reducing techniques, we were able to detect longitudinal changes in diffusion tensor imaging parameters in hemodialysis patients. The fractional anisotropy declines over the year indicate significant decreases in white matter health. However, we did not find that declines in fractional anisotropy was associated with declines in cognitive performance.
  
  
• Subjects:
  Brain Diffusion Tensor Imaging Humans Magnetic Resonance Imaging Renal Dialysis White Matter
• Keywords:
  Hemodialysis Kidney Disease White Matter Integrity
• Source:
  Hemodial Int. 28(2):178-187
• Pubmed ID:
  38351365
• Pubmed Central ID:
  PMC11014772
• Document Type:
  Journal Article
• Funding:
  K23 DK113119/DK/NIDDK NIH HHSUnited States/ ; TL1 TR001437/TR/NCATS NIH HHSUnited States/ ; U01 CE002944/CE/NCIPC CDC HHSUnited States/ ; NCATS TL-1TR001437/NH/NIH HHSUnited States/
• Volume:
  28
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:2098aa0415165613a5c659f8fda84e7cb96c1313e7dfdf41543620a3bccce48334a2867d450e984918d0dd8315145600119dbb340b78dfd3d79e53494ff5ccc8
• Download URL:
  https://stacks.cdc.gov/view/cdc/169959/cdc_169959_DS1.pdf
• File Type:
  [PDF - 1.34 MB ]