TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

Sodsai, Pimpayao; Ittiwut, Chupong; Ruenjaiman, Vichaya; Ittiwut, Rungnapa; Jantarabenjakul, Watsamon; Suphapeetiporn, Kanya; Shotelersuk, Vorasuk; Hirankarn, Nattiya

doi:10.3201/eid2811.220914

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TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

11 2022
By Sodsai, Pimpayao ; Ittiwut, Chupong ; Ruenjaiman, Vichaya ; ...
http://dx.doi.org/10.3201/eid2811.220914
Source: Emerg Infect Dis. 2022; 28(11):2350-2352

[PDF-517.12 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Sodsai, Pimpayao ; Ittiwut, Chupong ; Ruenjaiman, Vichaya ; Ittiwut, Rungnapa ; Jantarabenjakul, Watsamon ; ... More +

Sodsai, Pimpayao ; Ittiwut, Chupong ; Ruenjaiman, Vichaya ; Ittiwut, Rungnapa ; Jantarabenjakul, Watsamon ; Suphapeetiporn, Kanya ; Shotelersuk, Vorasuk ; Hirankarn, Nattiya Less -
Description:

A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.
Subjects:

[+]

Codon, Nonsense COVID-19 Cytokines Humans Receptors, Immunologic SARS-COV-2
Source:

Emerg Infect Dis. 2022; 28(11):2350-2352
Pubmed ID:

36191906
Pubmed Central ID:

PMC9622227
Document Type:

Journal Article
Genre:

Letter
Place as Subject:

Thailand
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:a3211b4f760e8d520616d0f9adde4dacfab75679cb44f646c09a3be7953e7458
Download URL:

https://stacks.cdc.gov/view/cdc/122870/cdc_122870_DS1.pdf
File Type:

	22-0914-F.gif	gif
	22-0914-F.jpg	jpeg
	22-0914-Techapp-s1.pdf	pdf
	22-0914.nxml	xml

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