TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sodsai, Pimpayao ; Ittiwut, Chupong ; Ruenjaiman, Vichaya ; Ittiwut, Rungnapa ; Jantarabenjakul, Watsamon ; Suphapeetiporn, Kanya ; Shotelersuk, Vorasuk ; Hirankarn, Nattiya
• Description:
  A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.
• Subjects:
  Codon, Nonsense COVID-19 Cytokines Humans Receptors, Immunologic SARS-COV-2
• Source:
  Emerg Infect Dis. 2022; 28(11):2350-2352
• Pubmed ID:
  36191906
• Pubmed Central ID:
  PMC9622227
• Document Type:
  Journal Article
• Genre:
  Letter
• Place as Subject:
  Thailand
• Volume:
  28
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a3211b4f760e8d520616d0f9adde4dacfab75679cb44f646c09a3be7953e7458
• Download URL:
  https://stacks.cdc.gov/view/cdc/122870/cdc_122870_DS1.pdf
• File Type:
  [PDF - 517.12 KB ]