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Differences in SARS-CoV-2 Clinical Manifestations and Disease Severity in Children and Adolescents by Infecting Variant

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File Language:
English


Details

  • Alternative Title:
    Emerg Infect Dis
  • Personal Author:
  • Description:
    Since the COVID-19 pandemic began, different SARS-CoV-2 variants have been identified and associated with higher transmissibility than the ancestral nonvariant strain. During January 1, 2021-January 15, 2022, we assessed differences in clinical and viral parameters in a convenience sample of COVID-19 outpatients and inpatients 0-21 years of age in Columbus, Ohio, USA, according to the infecting variant, identified using a mutation-specific reverse transcription PCR assay. Of the 676 patients in the study, 17.75% were infected with nonvariant strains, 18.49% with the Alpha variant, 41.72% with Delta, and 16.42% with Omicron. Rates of SARS-COV-2/viral co-infections were 15.66%-29.41% and were comparable across infecting variants. Inpatients with acute Delta and Omicron infections had lower SARS-CoV-2 cycle threshold values and more frequent fever and respiratory symptoms than those with nonvariant strain infections. In addition, SARS-COV-2/viral co-infections and the presence of underlying conditions were independently associated with worse clinical outcomes, irrespective of the infecting variant.
  • Subjects:
  • Source:
    Emerg Infect Dis. 2022; 28(11):2270-2280
  • Pubmed ID:
    36285986
  • Pubmed Central ID:
    PMC9622241
  • Document Type:
    Journal Article
  • Funding:
    U01 AI131386/AI/NIAID NIH HHSUnited States/
  • Place as Subject:
    United States
  • Volume:
    28
  • Issue:
    11
  • Collection(s):
  • Main Document Checksum:
    urn:sha256:91553d00855ed77be56a8a3a85e4b62ed912f0df66a9294fff082d308d2e8ef1
  • Download URL:
  • File Type:
    Filetype[PDF - 1.52 MB ]
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