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Quantification of multidrug-resistant M. tuberculosis bacilli in sputum during the first 8 weeks of treatment
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11 01 2022
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Source: Int J Tuberc Lung Dis. 26(11):1058-1064
[PDF-424.04 KB]
Details:
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Alternative Title:Int J Tuberc Lung Dis
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Personal Author:
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Description:SETTING:
Mulago Hospital, Kampala, Uganda.
OBJECTIVE:
To quantify Mycobacterium tuberculosis in sputum during the first 8 weeks of pulmonary multidrug-resistant TB (MDR-TB) treatment.
DESIGN:
We enrolled consecutive adults with pulmonary MDR-TB treated according to national guidelines. We collected overnight sputum samples before treatment and weekly. Sputum samples were cultured on Middlebrook 7H11S agar to measure colony-forming units per mL (cfu/mL) and in MGIT™ 960™ media to measure time to detection (TTD). Linear mixed-effects regression was used to estimate the relational change in log10 cfu/mL and TTD.
RESULTS:
Twelve adults (median age: 27 years) were enrolled. Half were women, and two-thirds were HIV-positive. At baseline, median log10 cfu/mL was 5.1, decreasing by 0.29 log10 cfu/mL/week. The median TTD was 116.5 h, increasing in TTD by 36.97 h/week. The weekly change was greater in the first 2 weeks (−1.04 log10 cfu/mL/week and 120.02 h/week) than in the remaining 6 weeks (−0.17 log10 cfu/mL/week and 26.11 h/week).
CONCLUSION:
Serial quantitative culture measures indicate a slow, uneven rate of decline in sputum M. tuberculosis over 8 weeks of standardized pulmonary MDR-TB treatment.
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Source:
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Pubmed ID:36281051
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Pubmed Central ID:PMC9720669
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Document Type:
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Funding:
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Volume:26
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Issue:11
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