Progressive, long-term hearing loss in congenital CMV disease after ganciclovir therapy

Details

• Alternative Title:
  J Pediatric Infect Dis Soc
• Personal Author:
  Lanzieri, Tatiana M. ; Caviness, A. Chantal ; Blum, Peggy ; Demmler-Harrison, Gail
• Description:
  Background:
  
  Long-term hearing outcomes among children with symptomatic congenital cytomegalovirus (CMV) disease who received 6-week ganciclovir therapy early in life are unknown.
  
  Methods:
  
  Longitudinal study of 76 children with symptomatic congenital CMV disease, born 1983–2005, who were categorized into three groups: A) treated with ganciclovir; B) untreated who had microcephaly, chorioretinitis or sensorineural hearing loss (SNHL; ≥25 dB) diagnosed in the first month of life (congenital); and C) untreated who did not meet criteria for group B.
  
  Results:
  
  Patients in groups A (n=17), B (n=27), and C (n=32) were followed to median age of 13, 11, and 13 years, respectively. In group A, patients received ganciclovir for median 40 (range: 11–63) days; 7 (41%) had grade 3 or 4 neutropenia. Congenital SNHL was diagnosed in 11 (65%) patients in group A, 15 (56%) in group B, and none in group C. Early-onset SNHL was diagnosed between ages ≥1–12 months in an additional 4 (24%), 6 (22%), and 8 (25%) patients in groups A, B and C, respectively. By the end of follow-up, 12 (71%), 16 (59%), and 7 (22%) of patients in groups A, B, and C, respectively, had severe (>70 dB) SNHL in the better-hearing ear.
  
  Conclusions:
  
  In this study, most patients with symptomatic congenital CMV disease and congenital or early-onset SNHL eventually developed hearing loss severe enough to have been potential candidates for cochlear implantation, with or without 6-week ganciclovir therapy. Understanding long-term hearing outcomes of patients treated with 6-month oral valganciclovir (current standard of care) is needed.
  
  
• Subjects:
  Antiviral Agents Article Child Congenital Cytomegalovirus Cytomegalovirus Infections Ganciclovir Hearing Loss Humans Infant Longitudinal Studies Sensorineural Hearing Loss

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• Source:
  J Pediatric Infect Dis Soc. 11(1):16-23
• Pubmed ID:
  34718680
• Pubmed Central ID:
  PMC9590555
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  11
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6c810cb75d86ef36b2f0eee6e001890310d48ffeb2160639ca6b80630aa26083
• Download URL:
  https://stacks.cdc.gov/view/cdc/121919/cdc_121919_DS1.pdf
• File Type:
  [PDF - 314.60 KB ]