A Longitudinal Assessment of Diabetes Autoantibodies in the SEARCH for Diabetes in Youth study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Merjaneh, Lina ; Dolan, Lawrence M. ; Suerken, Cynthia K. ; D’Agostino, Ralph ; Imperatore, Giuseppina ; Saydah, Sharon ; Roberts, Alissa ; Marcovina, Santica ; Mayer-Davis, Elizabeth J ; Dabelea, Dana ; Lawrence, Jean M. ; Pihoker, Catherine
• Description:
  Objective:
  
  To assess changes in diabetes autoantibodies (DAs) over time in children and young adults with diabetes and determine whether observed changes were associated with demographic characteristics, clinical parameters and diabetes complications.
  
  Research design and methods:
  
  Participants had DAs measured at baseline (10.3 ± 7.1 months after diabetes diagnosis) and at 12, 24 months and ≥ 5 years after the baseline measurement. At the ≥ 5-year follow-up, presence of diabetes complications was assessed. We examined the associations between change in number of positive DAs and changes in individual DA status with the participants’ characteristics and clinical parameters over time.
  
  Results:
  
  Out of 4179 participants, 62% had longitudinal DA data and 51% had complications and longitudinal DA data. In participants with ≥ 1 baseline positive DA (n=1699), 83.4% remained positive after 7.3±2.3 years duration of diabetes. Decrease in number of positive DAs was associated with longer diabetes duration (p=0.003 for 1 baseline positive DA; p<0.001 for 2 baseline positive DAs) and younger age at diagnosis (p<0.001 for 2 baseline positive DAs). No associations were found between change in number of positive DAs in participants with ≥ 1 baseline positive DA (n=1391) and HbA1c, insulin dose, acute or chronic complications after 7.7±1.9 years duration of diabetes.
  
  Conclusions:
  
  DA status likely remains stable in the first 7 years after diabetes diagnosis. Younger age at diabetes diagnosis and longer duration were associated with less persistence of DAs. Measuring DAs after initial presentation may aid in diabetes classification but not likely in predicting the clinical course.
  
  
• Keywords:
  Adolescent Autoantibodies Child Diabetes Mellitus Glycated Hemoglobin Humans Insulin Time Factors Young Adult
• Source:
  Pediatr Diabetes. 23(7):1027-1037
• Pubmed ID:
  36054435
• Pubmed Central ID:
  PMC9588609
• Document Type:
  Journal Article
• Funding:
  U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; U18 DP006131/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006134/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006133/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK127208/DK/NIDDK NIH HHSUnited States/ ; UL1 TR000062/TR/NCATS NIH HHSUnited States/ ; UL1 TR001450/TR/NCATS NIH HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/ ; U18 DP006138/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  23
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:06ec5bf8445a72d98e5e6510a32395724816b21550fce3b393694bb35c8380a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/121915/cdc_121915_DS1.pdf
• File Type:
  [PDF - 434.57 KB ]