Details:

Alternative Title:
Pediatr Diabetes
Publisher's site:
http://dx.doi.org/10.1111/pedi.13403
Personal Author:
Merjaneh, Lina ; Dolan, Lawrence M. ; Suerken, Cynthia K. ; D’Agostino, Ralph ; Imperatore, Giuseppina ; ... More +
Merjaneh, Lina ; Dolan, Lawrence M. ; Suerken, Cynthia K. ; D’Agostino, Ralph ; Imperatore, Giuseppina ; Saydah, Sharon ; Roberts, Alissa ; Marcovina, Santica ; Mayer-Davis, Elizabeth J ; Dabelea, Dana ; Lawrence, Jean M. ; Pihoker, Catherine Less -
Description:
Objective:

To assess changes in diabetes autoantibodies (DAs) over time in children and young adults with diabetes and determine whether observed changes were associated with demographic characteristics, clinical parameters and diabetes complications.

Research design and methods:

Participants had DAs measured at baseline (10.3 ± 7.1 months after diabetes diagnosis) and at 12, 24 months and ≥ 5 years after the baseline measurement. At the ≥ 5-year follow-up, presence of diabetes complications was assessed. We examined the associations between change in number of positive DAs and changes in individual DA status with the participants’ characteristics and clinical parameters over time.

Results:

Out of 4179 participants, 62% had longitudinal DA data and 51% had complications and longitudinal DA data. In participants with ≥ 1 baseline positive DA (n=1699), 83.4% remained positive after 7.3±2.3 years duration of diabetes. Decrease in number of positive DAs was associated with longer diabetes duration (p=0.003 for 1 baseline positive DA; p<0.001 for 2 baseline positive DAs) and younger age at diagnosis (p<0.001 for 2 baseline positive DAs). No associations were found between change in number of positive DAs in participants with ≥ 1 baseline positive DA (n=1391) and HbA1c, insulin dose, acute or chronic complications after 7.7±1.9 years duration of diabetes.

Conclusions:

DA status likely remains stable in the first 7 years after diabetes diagnosis. Younger age at diabetes diagnosis and longer duration were associated with less persistence of DAs. Measuring DAs after initial presentation may aid in diabetes classification but not likely in predicting the clinical course.


Subject:
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Adolescent Article Autoantibodies Child Diabetes Mellitus Glycated Hemoglobin A Humans Insulin Time Factors Young Adult
Source:
Pediatr Diabetes. 23(7):1027-1037
Pubmed ID:
36054435
Pubmed Central ID:
PMC9588609
Document Type:
Journal Article
Funding:
U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; University of Colorado Denver/ ; U48/CCU519239/Cincinnati's Children's Hospital Medical Center/ ; U18DP000247-06A1/University of North Carolina at Chapel Hill/ ; U18DP002710-01/Seattle Children's Hospital/ ; ... More +
U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; University of Colorado Denver/ ; U48/CCU519239/Cincinnati's Children's Hospital Medical Center/ ; U18DP000247-06A1/University of North Carolina at Chapel Hill/ ; U18DP002710-01/Seattle Children's Hospital/ ; U18DP002714/Kaiser Permanente Southern California/ ; U48/CCU419249/University of North Carolina at Chapel Hill/ ; U18DP002708/University of North Carolina at Chapel Hill/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; 200-2010-35171/Wake Forest University School of Medicine/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; CC/CDC HHSUnited States/ ; UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; 1U18DP006131/The Population Based Registry of Diabetes in Youth Study/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006134/ACL/ACL HHSUnited States/ ; U48/CCU919219/Kaiser Permanente Southern California/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006133/ACL/ACL HHSUnited States/ ; NH/NIH HHSUnited States/ ; U48/CCU819241-3/University of North Carolina at Chapel Hill/ ; U18DP006136/ACL/ACL HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006139/ACL/ACL HHSUnited States/ ; 1U18DP002709/Cincinnati's Children's Hospital Medical Center/ ; U48/CCU919219/Wake Forest University School of Medicine/ ; R01 DK127208/DK/NIDDK NIH HHSUnited States/ ; U58/CCU019235-4/Seattle Children's Hospital/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:06ec5bf8445a72d98e5e6510a32395724816b21550fce3b393694bb35c8380a3
File Type:

• Supporting Files:
  No Additional Files

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