Adenovirus Serotype 3 and 7 Infection with Acute Respiratory Failure in Children in Taiwan, 2010–2011

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Lai, Chen-Yin ; Lee, Chia-Jie ; Lu, Chun-Yi ; Lee, Ping-Ing ; Shao, Pei-Lan ; Wu, En-Ting ; Wang, Ching-Chia ; Tan, Boon-Fatt ; Chang, Hsin-Yu ; Hsia, Shao-Hsuan ; Lin, Jainn-Jim ; Chang, Luan-Yin ; Huang, Yhu-Chering ; Huang, Li-Min
• Corporate Authors:
  on behalf of the Taiwan Pediatric Infectious Disease Alliance
• Description:
  Objective
  
  Increased incidence of adenovirus infection in children was noticed since September 2010 in Taiwan and severe cases requiring intensive care were noted later. We did this study to find the clinical characteristics and risk factors associated with severe adenovirus infection.
  
  Patients and Methods
  
  We collected cases of severe adenovirus infection between November 2010 and June 2011 to analyze their clinical characteristics in two medical centers in northern Taiwan. Severe adenovirus infection was defined as laboratory-confirmed adenovirus cases with required intensive care. Hexon gene sequencing was performed for molecular genotyping.
  
  Results
  
  45 patients were included, 22 cases (49%) were infected with serotype 7, 19 (42%) with serotype 3, and 4 with serotype 2. The median age (range) was 2.75 years (0.08–15.43 years); 87% were below 5 years. Male to female ratio was 1.65 (28 to 17). Of these patients, 56% had underlying neurological diseases, 50% experienced fever higher than 40°C and 69% suffered fever longer than one week. The clinical diagnosis included pneumonia in 40 (89%) patients, bronchopneumonia in 5 (11%), and encephalitis in 7 (16%). At least 22 patients had pleural effusion. They had complications of respiratory failure (53%), acute respiratory distress syndrome (24%), hypotension (40%), and 6 (13%) patients needed extracorporeal membranous oxygenation. Ten (22%) patients died, all with underlying major systemic diseases and 7 (70%) infected with serotype 7.
  
  Conclusions
  
  Adenovirus serotype 7 and 3 can cause severe disease–even death–in children, especially those with underlying neurological diseases. Patients infected with adenovirus serotype 7 tended to have a higher case-fatality rate.
  
  
• Subjects:
  Acute Disease Adenoviruses, Human Adenovirus Infections, Human Adolescent Child Child, Preschool Demography Female Humans Infant Intensive Care Units Male Phylogeny Radiography, Thoracic Respiratory Insufficiency Serotyping Treatment Outcome

  More +
• Source:
  PLoS One. 2013; 8(1).
• Document Type:
  Journal Article
• Place as Subject:
  Taiwan
• Volume:
  8
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3d63167289bf79ff569fe5bf07b52eb80b5d2278442bc23159580650b3b566d5
• Download URL:
  https://stacks.cdc.gov/view/cdc/12189/cdc_12189_DS1.pdf
• File Type:
  [PDF - 269.95 KB ]