Melanoma in women of childbearing age and in pregnancy in California, 1994–2015: a population-based cohort study

Details

• Alternative Title:
  J Eur Acad Dermatol Venereol
• Personal Author:
  Kiuru, M. ; Li, Q. ; Zhu, G. ; Terrell, J.R. ; Beroukhim, K. ; Maverakis, E. ; Keegan, T.H.M.
• Description:
  Background:
  
  Melanoma is one of the most common malignancies during pregnancy. There is debate regarding the impact of pregnancy on the prognosis of melanoma. Recent large population-based studies from the United States are lacking.
  
  Objectives:
  
  To determine the characteristics and survival of women with pregnancy-associated melanoma.
  
  Methods:
  
  This population-based, retrospective cohort study used California Cancer Registry data linked with statewide hospitalization and ambulatory surgery data to identify 15–44-year-old female patients diagnosed with melanoma in 1994–2015, including pregnant patients. Multivariable logistic regression compared demographic and clinical characteristics between pregnant and non-pregnant women with melanoma. Multivariable cox proportional hazards regression models assessed melanoma specific and overall survival.
  
  Results:
  
  We identified 13108 patients, of which 1406 were pregnant. Pregnancy-associated melanoma was more frequent in Hispanic compared to non-Hispanic White women. Melanoma occurring postpartum was associated with greater tumor thickness (2.01–4.00 vs 0.01–1.00 mm, odds ratio 1.75, 95% confidence interval: 1.03–2.98). There were otherwise no significant differences between pregnant and non-pregnant women. Worse survival was associated with Asian, Black and Native American race/ethnicity (versus non-Hispanic White), lower neighborhood socioeconomic status, public insurance, tumor site, greater tumor thickness, and lymph node involvement, but not pregnancy.
  
  Conclusions:
  
  Melanoma occurring postpartum was associated with greater tumor thickness, but pregnancy status did not affect survival after melanoma. Race/ethnicity, socioeconomic status and health insurance impacted survival, emphasizing the importance of reducing health disparities.
  
  
• Keywords:
  Adolescent Adult California Cohort Studies Epidemiology Ethnicity Female Humans Management Melanoma Melanoma In Pregnancy Pregnancy Pregnancy-associated Melanoma Retrospective Studies Skin Cancer Survival United States Young Adult

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• Source:
  J Eur Acad Dermatol Venereol. 36(11):2025-2035
• Pubmed ID:
  35870141
• Pubmed Central ID:
  PMC9560982
• Document Type:
  Journal Article
• Funding:
  K23AR074530/AR/NIAMS NIH HHSUnited States/ ; K23 AR074530/AR/NIAMS NIH HHSUnited States/ ; P30CA093373-16/CA/NCI NIH HHSUnited States/ ; University of Southern California/ ; Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship/ ; CC/CDC HHSUnited States/ ; P30 CA093373/CA/NCI NIH HHSUnited States/ ; Career Development Award in Dermatopathology/Dermatology Foundation/ ; NH/NIH HHSUnited States/ ; University of California, San Francisco/ ; Department of Dermatology at University of California Davis/ ; Public Health Institute/ ; California Department of Public Health/
• Volume:
  36
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0d6c99d0c6f98b8ef2ae15ba860f6bfc865ab91ee0eb1eff029b7b25b92a97ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/121810/cdc_121810_DS1.pdf
• File Type:
  [PDF - 139.47 KB ]