Efficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: a post hoc analysis of Da Qing Diabetes Prevention Outcome Study

Details

• Alternative Title:
  Diabetes Obes Metab
• Personal Author:
  Gong, Qiuhong ; Zhang, Ping ; Wang, Jinping ; Gregg, Edward W. ; Cheng, Yiling J. ; Li, Guangwei ; Bennett, Peter H.
• Corporate Authors:
  Da Qing Diabetes Prevention Outcome Study Group
• Description:
  Aims ; The extent that pre-diabetic fasting plasma glucose (FPG) levels influence the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2DM) is uncertain. We aimed to determine if the outcome of lifestyle intervention in people with impaired glucose tolerance (IGT) differs in those with normal or impaired FPG levels. ; Methods ; Using data from the Da Qing Diabetes Prevention Outcome Study, a 30-year follow-up of a six-year randomized trial of lifestyle intervention in 576 people with IGT, we conducted a post-hoc analysis to compare the efficacy of intervention to reduce the incidence of T2DM and its complications in those with baseline FPG <100mg/dL and FPG ≥100 mg/dL. ; Results ; Lifestyle intervention reduced the cumulative incidence of T2DM by 37–46% in those with baseline FPG <100mg/dL and by 47–51% in those with FPG ≥100 mg/dL. The FPG <100 mg/dL group had a lower cumulative incidence of diabetes and 6.41years median delay in its onset compared with 2.21 years delay in the FPG >100 mg/dL group. In those with FPG <100 mg/dL intervention was associated with at least as great a reduction in cardiovascular disease (CVD) and all-cause mortality as in the FPG >100 mg/dL group. ; Conclusions ; Lifestyle intervention reduced the incidence of T2DM in people with IGT regardless of baseline FPG levels, and in those with FPG <100 mg/dL led to a substantial delay in its onset. All persons with IGT, with normal or impaired FPG levels, may benefit from lifestyle intervention to delay its onset and mitigate the incidence of T2DM.
• Subjects:
  • Adult
  • Blood Glucose
  • Diabetes Mellitus, Type 2
  • Fasting
  • Glucose Intolerance
  • Humans
  • Life Style
  • Outcome Assessment, Health Care
  • Prediabetic State
• Keywords:
  • lifestyle intervention
  • impaired glucose intolerance
  • impaired fasting glucose
  • type 2 diabetes
  • Da Qing Study
• Source:
  Diabetes Obes Metab. 23(10):2385-2394
• Pubmed ID:
  34212465
• Pubmed Central ID:
  PMC8429240
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U19 GH000636/GH/CGH CDC HHSUnited States/ ; U19GH000636/ACL/ACL HHSUnited States/
• Volume:
  23
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/121653/cdc_121653_DS1.pdf
• File Type:
  [PDF - 480.07 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:40bdc2db72ee7b3924191cd748b6ad976afe0e54adb0af9a6ff7f80aa3148dc04c474f87c197835d435410223df1c7ba74ce7e656264dbb8b063fba9150d75e4