Impairment of Coronary Arteriolar Endothelium-Dependent Dilation after Multi-Walled Carbon Nanotube Inhalation: A Time-Course Study

Stapleton, Phoebe A.; Minarchick, Valerie C.; Cumpston, Amy M.; McKinney, Walter; Chen, Bean T.; Sager, Tina M.; Frazer, David G.; Mercer, Robert R.; Scabilloni, James; Andrew, Michael E.; Castranova, Vincent; Nurkiewicz, Timothy R.

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

i

Impairment of Coronary Arteriolar Endothelium-Dependent Dilation after Multi-Walled Carbon Nanotube Inhalation: A Time-Course Study

Oct 24 2012
By Stapleton, Phoebe A. ; Minarchick, Valerie C. ; Cumpston, Amy M. ; ...
Source: Int J Mol Sci. 2012; 13(11):13781-13803.

[PDF-3.03 MB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Int J Mol Sci
Personal Author:

Stapleton, Phoebe A. ; Minarchick, Valerie C. ; Cumpston, Amy M. ; McKinney, Walter ; Chen, Bean T. ; ... More +

Stapleton, Phoebe A. ; Minarchick, Valerie C. ; Cumpston, Amy M. ; McKinney, Walter ; Chen, Bean T. ; Sager, Tina M. ; Frazer, David G. ; Mercer, Robert R. ; Scabilloni, James ; Andrew, Michael E. ; Castranova, Vincent ; Nurkiewicz, Timothy R. Less -
Description:

Engineered nanomaterials have been developed for widespread applications due to many highly unique and desirable characteristics. The purpose of this study was to assess pulmonary inflammation and subepicardial arteriolar reactivity in response to multi-walled carbon nanotube (MWCNT) inhalation and evaluate the time course of vascular alterations. Rats were exposed to MWCNT aerosols producing pulmonary deposition. Pulmonary inflammation via bronchoalveolar lavage and MWCNT translocation from the lungs to systemic organs was evident 24 h post-inhalation. Coronary arterioles were evaluated 24-168 h post-exposure to determine microvascular response to changes in transmural pressure, endothelium-dependent and -independent reactivity. Myogenic responsiveness, vascular smooth muscle reactivity to nitric oxide, and α-adrenergic responses all remained intact. However, a severe impact on endothelium-dependent dilation was observed within 24 h after MWCNT inhalation, a condition which improved, but did not fully return to control after 168 h. In conclusion, results indicate that MWCNT inhalation not only leads to pulmonary inflammation and cytotoxicity at low lung burdens, but also a low level of particle translocation to systemic organs. MWCNT inhalation also leads to impairments of endothelium-dependent dilation in the coronary microcirculation within 24 h, a condition which does not fully dissipate within 168 h. The innovations within the field of nanotechnology, while exciting and novel, can only reach their full potential if toxicity is first properly assessed.
Subjects:

[+]

Acetylcholine Administration, Inhalation Animals Arterial Pressure Bronchoalveolar Lavage Fluid Coronary Vessels Dilatation, Pathologic Dose-Response Relationship, Drug Endothelium, Vascular Heart Kidney Liver Lung Male Muscle, Smooth, Vascular Myocardium Nanotubes, Carbon Nitroprusside Organ Size Phenylephrine Pneumonia Rats Time Factors
Source:

Int J Mol Sci. 2012; 13(11):13781-13803.
Document Type:

Journal Article
Volume:

13
Issue:

11
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:c2fa42a7470d0b627deee0f875527fde390f3593916c40750e5f02196cbdf9db
Download URL:

https://stacks.cdc.gov/view/cdc/12158/cdc_12158_DS1.pdf
File Type:

	ijms-13-13781f3.jpg	jpeg
	ijms-13-13781f4.gif	gif
	ijms-13-13781f4.jpg	jpeg
	ijms-13-13781f5.gif	gif
	ijms-13-13781f5.jpg	jpeg
	ijms-13-13781f6.gif	gif
	ijms-13-13781f6.jpg	jpeg
	ijms-13-13781f7.gif	gif
	ijms-13-13781f7.jpg	jpeg
	ijms-13-13781f8.gif	gif
	ijms-13-13781.nxml	txt
	ijms-13-13781f8.jpg	jpeg
	ijms-13-13781f9.gif	gif
	ijms-13-13781f9.jpg	jpeg
	license.txt	txt
	ijms-13-13781f1.gif	gif
	ijms-13-13781f1.jpg	jpeg
	ijms-13-13781f10.gif	gif
	ijms-13-13781f10.jpg	jpeg
	ijms-13-13781f2.gif	gif
	ijms-13-13781f2.jpg	jpeg
	ijms-13-13781f3.gif	gif

More +