Age-Dependent Effects of COVID-19 Vaccine and of Healthcare Burden on COVID-19 Deaths, Tokyo, Japan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ko, Yura K. ; Murayama, Hiroaki ; Yamasaki, Lisa ; Kinoshita, Ryo ; Suzuki, Motoi ; Nishiura, Hiroshi
• Description:
  COVID-19 vaccine effectiveness against death in Japan remains unknown. Furthermore, although evidence indicates that healthcare capacity influences case-fatality risk (CFR), it remains unknown whether this relationship is mediated by age. With a modeling study, we analyzed daily COVID-19 cases and deaths during January-August 2021 by using Tokyo surveillance data to jointly estimate COVID-19 vaccine effectiveness against death and age-specific CFR. We also examined daily healthcare operations to determine the association between healthcare burden and age-specific CFR. Among fully vaccinated patients, vaccine effectiveness against death was 88.6% among patients 60-69 years of age, 83.9% among patients 70-79 years of age, 83.5% among patients 80-89 years of age, and 77.7% among patients >90 years of age. A positive association of several indicators of healthcare burden with CFR among patients >70 years of age suggested an age-dependent effect of healthcare burden on CFR in Japan.
• Subjects:
  Aged Aged, 80 And Over COVID-19 COVID-19 Vaccines COVID-19/Mortality Delivery Of Health Care Humans SARS-COV-2
• Source:
  Emerg Infect Dis. 2022; 28(9):1777-1784
• Pubmed ID:
  35820166
• Pubmed Central ID:
  PMC9423928
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Volume:
  28
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:18d1e5036a26615284b594fd55b26e045f8a982f92126ea1a42a4da56bd72054
• Download URL:
  https://stacks.cdc.gov/view/cdc/121046/cdc_121046_DS1.pdf
• File Type:
  [PDF - 1.84 MB ]