Detection of Endosymbiont Candidatus Midichloria mitochondrii and Tickborne Pathogens in Humans Exposed to Tick Bites, Italy

Sgroi, Giovanni; Iatta, Roberta; Lovreglio, Piero; Stufano, Angela; Laidoudi, Younes; Mendoza-Roldan, Jairo Alfonso; Bezerra-Santos, Marcos Antonio; Veneziano, Vincenzo; Di Gennaro, Francesco; Saracino, Annalisa; Chironna, Maria; Bandi, Claudio; Otranto, Domenico

doi:10.3201/eid2809.220329

i

Detection of Endosymbiont Candidatus Midichloria mitochondrii and Tickborne Pathogens in Humans Exposed to Tick Bites, Italy

Supporting Files Public Domain

9 2022
By Sgroi, Giovanni ; Iatta, Roberta ; Lovreglio, Piero ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Sgroi, Giovanni ; Iatta, Roberta ; Lovreglio, Piero ; Stufano, Angela ; Laidoudi, Younes ; Mendoza-Roldan, Jairo Alfonso ; Bezerra-Santos, Marcos Antonio ; Veneziano, Vincenzo ; Di Gennaro, Francesco ; Saracino, Annalisa ; Chironna, Maria ; Bandi, Claudio ; Otranto, Domenico
Description:

During 2021, we collected blood and serum samples from 135 persons exposed to tick bites in southern Italy. We serologically and molecularly screened for zoonotic tickborne pathogens and only molecularly screened for Candidatus Midichloria mitochondrii. Overall, 62 (45.9%) persons tested positive for tickborne pathogens. Coxiella burnetii was detected most frequently (27.4%), along with Rickettsia spp. (21.5%) and Borrelia spp. (10.4%). We detected Candidatus M. mitochondrii DNA in 46 (34.1%) participants who had statistically significant associations to tickborne pathogens (p<0.0001). Phylogenetic analysis of Candidatus M. mitochondrii sequences revealed 5 clades and 8 human sequence types that correlated with vertebrates, Ixodes spp. ticks, and countries in Europe. These data demonstrated a high circulation of tickborne pathogens and Candidatus M. mitochondrii DNA in persons participating in outdoor activities in southern Italy. Our study shows how coordinated surveillance among patients, clinicians, and veterinarians could inform a One Health approach for monitoring and controlling the circulation of tickborne pathogens.
Subjects:

Animals Humans Ixodes Phylogeny Rickettsia Rickettsiales Tick Bites
Source:

Emerg Infect Dis. 2022; 28(9):1824-1832
Pubmed ID:

35997363
Pubmed Central ID:

PMC9423927
Document Type:

Journal Article
Place as Subject:

Italy
Volume:

28
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:b0134d7f9094e3cf4f009427e3f3316d37a9c29ab76610b49812bbd65eeed5c1
Download URL:

https://stacks.cdc.gov/view/cdc/121044/cdc_121044_DS1.pdf
File Type:

[PDF - 1.73 MB ]

File Language:

English

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