Factors Associated with Severe Outcomes Among Immunocompromised Adults Hospitalized for COVID-19 — COVID-NET, 10 States, March 2020–February 2022

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Singson, Jason Robert C. ; Kirley, Pam Daily ; Pham, Huong ; Rothrock, Gretchen ; Armistead, Isaac ; Meek, James ; Anderson, Evan J. ; Reeg, Libby ; Lynfield, Ruth ; Ropp, Susan ; Muse, Alison ; Felsen, Christina B. ; Sutton, Melissa ; Talbot, H. Keipp ; Havers, Fiona P. ; Taylor, Christopher A. ; Reingold, Arthur ; Chai, Shua J. ; Alden, Nisha B. ; Yousey-Hindes, Kim ; Openo, Kyle P. ; Bye, Erica ; Montoya, Mark A. ; Barney, Grant ; Popham, Kevin ; Abdullah, Nasreen ; Schaffner, William
• Corporate Authors:
  COVID-NET Surveillance Team
• Description:
  Immunocompromised persons are at increased risk for severe COVID-19-related outcomes, including intensive care unit (ICU) admission and death (1). Data on adults aged ≥18 years hospitalized with laboratory-confirmed COVID-19 from 10 U.S. states in the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) were analyzed to assess associations between immunocompromise and ICU admission and in-hospital death during March 1, 2020-February 28, 2022. Associations of COVID-19 vaccination status with ICU admission and in-hospital death were also examined during March 1, 2021-February 28, 2022. During March 1, 2020-February 28, 2022, among a sample of 22,345 adults hospitalized for COVID-19, 12.2% were immunocompromised. Among unvaccinated patients, those with immunocompromise had higher odds of ICU admission (adjusted odds ratio [aOR] = 1.26; 95% CI = 1.08-1.49) and in-hospital death (aOR = 1.34; 95% CI = 1.05-1.70) than did nonimmunocompromised patients. Among vaccinated patients,* those with immunocompromise had higher odds of ICU admission (aOR = 1.40; 95% CI = 1.01-1.92) and in-hospital death (aOR = 1.87; 95% CI = 1.28-2.75) than did nonimmunocompromised patients. During March 1, 2021-February 28, 2022, among nonimmunocompromised patients, patients who were vaccinated had lower odds of death (aOR = 0.58; 95% CI = 0.39-0.86) than did unvaccinated patients; among immunocompromised patients, odds of death between vaccinated and unvaccinated patients did not differ. Immunocompromised persons need additional protection from COVID-19 and using multiple known COVID-19 prevention strategies,| including nonpharmaceutical interventions, up-to-date vaccination of immunocompromised persons and their close contacts,| early testing, and COVID-19 prophylactic (Evusheld) and early antiviral treatment,| can help prevent hospitalization and subsequent severe COVID-19 outcomes among immunocompromised persons.
• Subjects:
  Adolescent Adult COVID-19 COVID-19 Vaccines Hospitalization Hospital Mortality Humans Immunocompromised Host
• Source:
  MMWR Morbidity Mortal Weekly Rep. 71(27):878-884
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7127a3
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  35797216
• Pubmed Central ID:
  PMC9290380
• Document Type:
  Journal Article
• Pages in Document:
  7 pdf pages
• Volume:
  71
• Issue:
  27
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:30a914341c35590f91634d411e9f2c40a887d0d64d1fef9e8c45b533afff20209a2af4fe929637f287575cdafc98917a56e509d479a32b57124bf331b88a6c43
• Download URL:
  https://stacks.cdc.gov/view/cdc/119940/cdc_119940_DS1.pdf
• File Type:
  [PDF - 147.56 KB ]