Years of life lost to cancer among the US HIV population, 2006–2015
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7 15 2022
Source: AIDS. 36(9):1279-1286
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Alternative Title:AIDS
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Description:Objectives:
We estimated years of life lost (YLLs) to all causes of death and years of life lost to cancer among persons living with human immunodeficiency virus (HIV; PLWH) in the United States (US).
Design:
Linked HIV and cancer registry data from the HIV/AIDS Cancer Match Study were used to identify incident cancers and deaths among PLWH in 11 regions of the US during 2006–2015.
Methods:
Mean YLL (MYLL) to all causes of death and MYLL to cancer during 2006–2015 were derived from the restricted mean survival estimated from Cox proportional hazards regression models. MYLLs were then upweighted to the national population of PLWH to obtain all-cause total years of life lost (TYLL) and cancer-related TYLL in the US during 2006–2015.
Results:
Among 466,234 PLWH in the study population, 25,772 (5.5%) developed cancer during 2006–2015. Nationally, an estimated 134,986 years of life were lost to cancer of all types during 2006–2015 among PLWH, representing 9.6% of TYLL to all causes. Non-Hodgkin lymphoma (NHL), Kaposi sarcoma (KS), anal cancer, and lung cancer were the four largest cancer contributors (45% of TYLL to cancer). The largest fraction of TYLL occurred among Black PLWH, men who have sex with men, and PLWH aged 40–59 years old.
Conclusion:
PLWH have higher mortality rates after developing cancer. NHL, KS, and anal and lung cancers were large contributors to years of life lost to cancer in the U.S. population of PLWH, highlighting opportunities to reduce cancer mortality through improved access to antiretroviral treatment, prevention, and screening.
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Pubmed ID:35608110
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Pubmed Central ID:PMC9283267
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Supporting Files:No Additional Files
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