Health and Cognition among Adults with and without Traumatic Brain Injury: A Matched Case-Control Study

Details

• Alternative Title:
  Brain Inj
• Personal Author:
  Kumar, Raj G. ; Ketchum, Jessica M. ; Hammond, Flora M. ; Novack, Thomas A. ; O’Neil-Pirozzi, Therese M. ; Silva, Marc A. ; Dams-O’Connor, Kristen
• Description:
  Objectives:
  
  To evaluate associations between traumatic brain injury (TBI) and presence of health conditions, and to compare associations of health and cognition between TBI cases and controls.
  
  Methods:
  
  This matched case-control study used data from the TBI Model Systems National Database (TBI cases) and Midlife in the United States (MIDUS) II and Refresher studies (controls). N=248 TBI cases were age-, sex-, race-, and education-matched without replacement to three controls. Cases and controls were compared on prevalence of 18 self-reported conditions, self-rated health, composite scores from the Brief Test of Adult Cognition by Telephone.
  
  Results:
  
  The following conditions were significantly more prevalent among TBI cases versus controls: anxiety/depression (OR=3.12, 95% CI: 2.20, 4.43, p<0.001), chronic sleeping problems (OR=2.76, 95% CI: 1.86, 4.10, p<0.001), headache/migraine (OR=2.61, 95% CI: 1.50, 4.54, p=0.0007), and stroke (OR=6.42, 95% CI: 2.93, 14.10, p<0.001). The relationship between self-rated health and cognition significantly varied by TBI (pinteraction=0.002).
  
  Conclusion:
  
  Individuals with TBI have greater odds of selected neurobehavioral conditions compared to their demographically-similar uninjured peers. Among persons with TBI there was a stronger association between poorer self-rated health and cognition than controls. TBI is increasingly conceptualized as a chronic disease; current findings suggest post-TBI health management requires cognitive supports.
  
  
• Subjects:
  Adult Brain Injuries, Traumatic Case-Control Studies Cognition Disorders Humans Self Report
• Source:
  Brain Inj. 36(3):415-423
• Pubmed ID:
  35143349
• Pubmed Central ID:
  PMC9205640
• Document Type:
  Journal Article
• Funding:
  K99 HD106060/HD/NICHD NIH HHSUnited States/ ; U48 DP000036/DP/NCCDPHP CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  36
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:56f54b8ab499e11d223f0d7669daae4a8da19698471b384322ad31865f2b2c05
• Download URL:
  https://stacks.cdc.gov/view/cdc/119287/cdc_119287_DS1.pdf
• File Type:
  [PDF - 443.24 KB ]