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Pre-Injury Health Status of Adults with Traumatic Brain Injury: A Preliminary Matched Case-Control Study
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2022
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Source: J Head Trauma Rehabil. 37(3):E186-E195
[PDF-652.15 KB]
Details:
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Alternative Title:J Head Trauma Rehabil
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Personal Author:
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Description:OBJECTIVE:
To discern whether there is evidence that individuals who sustained a traumatic brain injury (TBI) had greater odds of pre-existing health conditions and/or poorer health behaviors compared to matched controls without TBI.
SETTING:
Brain Injury Inpatient Rehabilitation Unit at Mount Sinai Hospital. Midlife in the United States (MIDUS) control data were collected via random-digit-dialing phone survey.
PARTICIPANTS:
TBI cases were enrolled into the TBI Health Study and met at least one of four injury severity criteria: abnormal computed tomography scan, Glasgow Coma Scale score between 3–12, loss of consciousness >30 minutes, or post-TBI amnesia longer than 24 hours. n=62 TBI cases and n=171 matched MIDUS controls were included in analyses; controls were excluded if they reported having a history of head injury.
DESIGN:
Matched Case-Control Study.
MAIN MEASURES:
Self-reported measures of depression symptoms, chronic pain, health status, alcohol use, smoking status, abuse of controlled substances, physical activity, physical health composite score, and behavioral health composite score.
RESULTS:
Pre-index injury depression was nearly 4 times higher in TBI cases compared to matched controls (OR=3.98 [95% CI=1.71–9.27, p-value=0.001]). We found no significant differences in the odds of self-reporting 3 or more medical health conditions in year prior to index injury (OR=1.52 [95% CI=0.82–2.81, p-value=0.183]) or reporting more risky health behaviors (OR= 1.48 [95% CI=0.75–2.91, p-value=0.254]) in individuals with TBI compared to controls.
CONCLUSION:
These preliminary findings suggest that odds of depression in the year prior to index injury far exceed those reported in matched controls. Further study in larger samples is required to better understand the relative odds of prior health problems in those who sustain a TBI, with a goal of elucidating the implications of pre-injury health on post-TBI disease burden.
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Pubmed ID:34145163
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Pubmed Central ID:PMC8671538
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