Safety and immunogenicity of adjuvanted recombinant subunit herpes zoster vaccine in lung transplant recipients

Details

• Alternative Title:
  Am J Transplant
• Personal Author:
  Hirzel, Cedric ; L'Huillier, Arnaud G. ; Ferreira, Victor H. ; Marinelli, Tina ; Ku, Terrance ; Ierullo, Matthew ; Miao, Congrong ; Schmid, D. Scott ; Juvet, Stephen ; Humar, Atul ; Kumar, Deepali
• Description:
  Lung transplant recipients are at high risk for herpes zoster and preventive measures are a significant unmet need. We investigated the safety and immunogenicity of two doses of a recombinant zoster vaccine (RZV) in lung transplant recipients (≥50 years). We enrolled 50 patients of which 49 received at least one vaccine dose. Anti-glycoprotein E (gE) antibody levels (n = 43) increased significantly compared to baseline (median optical density [OD] 1.96; interquartile range [IQR]: 1.17-2.89) after the first (median OD 3.41, IQR 2.54-3.81, p < .0001) and second vaccine dose (median OD 3.63, IQR 3.39-3.86, p < .0001). gE-specific polyfunctional CD4+ T cell frequencies (n = 38) also increased from baseline (median 85 per 10| CD4+ T cells; IQR: 46-180) to the first (median 128 per 10| CD4+ T cells; IQR: 82-353; p = .023) and after the second dose (median 361 per 10| CD4+ T cells; IQR: 146-848; p < .0001). Tenderness (83.0%; 95%CI: 69.2-92.4%) and redness (31.9%; 95%CI: 19.1-47.1%) at injection site were common. One rejection episode within 3 weeks of vaccination was observed. This is the first study demonstrating that RZV was safe and elicited significant humoral and cell-mediated immunity in lung transplant recipients. RZV is a new option for the prevention of shingles in this population.
• Subjects:
  Antibodies, Viral Herpes Zoster Herpes Zoster Vaccine Humans Lung Transplant Recipients
• Keywords:
  Clinical Research/Practice Complication: Infectious Infection And Infectious Agents - Viral Infectious Disease Lung Transplantation/Pulmonology Translational Research/ Science Vaccine
• Source:
  Am J Transplant. 21(6):2246-2253
• Pubmed ID:
  33565711
• Pubmed Central ID:
  PMC9169546
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  21
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a72757f30bfb5df3fcc964219d17ce080c12ce60a87a303d8e46af4374b711e8
• Download URL:
  https://stacks.cdc.gov/view/cdc/119232/cdc_119232_DS1.pdf
• File Type:
  [PDF - 829.80 KB ]