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Is Dietary Intake of Advanced Glycation End Products Associated with Mortality Among Adults with Diabetes?

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File Language:
English


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  • Alternative Title:
    Nutr Metab Cardiovasc Dis
  • Personal Author:
  • Description:
    Background and Aims

    Prior studies suggest a positive association between dietary AGEs and adverse health outcomes but have not well-characterized AGEs intake and its association with mortality in a general adult population in the United States.

    Methods and Results

    We included 5,474 adults with diabetes from the 2003 to 2018 National Health and Nutrition Examination Survey, a nationally representative sample of the non-institutionalized civilian population in the United States. Concordance to dietary guidelines (Healthy Eating Index 2015 [HEI-2015]) and intake of the AGE Nɛ-(carboxymethyl)lysine (CML) were estimated using an existing database and two 24-hour food recalls. Multivariable Cox regression evaluated the association between AGEs intake and all-cause mortality. A secondary analysis measured CML, Nɛ-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MGH1) from an alternative database.

    Conclusion

    While dietary AGEs intake was associated with concordance to dietary guidelines, it was not significantly associated with all-cause mortality among adults with diabetes. Further research may consider other health outcomes as well as the evaluating specific contribution of dietary AGEs to overall AGEs burden.

  • Subjects:
  • Source:
    Nutr Metab Cardiovasc Dis. 32(6):1402-1409
  • Pubmed ID:
    35282981
  • Pubmed Central ID:
    PMC9167219
  • Document Type:
    Journal Article
  • Funding:
    CC999999/ImCDC/Intramural CDC HHSUnited States/
  • Volume:
    32
  • Issue:
    6
  • Collection(s):
  • Main Document Checksum:
    urn:sha256:adba27fa9118df00bf13b59fceeab65704d2ecbf94b0b3632ebb2b04b6270e35
  • Download URL:
  • File Type:
    Filetype[PDF - 351.91 KB ]
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