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Is Dietary Intake of Advanced Glycation End Products Associated with Mortality Among Adults with Diabetes?
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6 2022
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Source: Nutr Metab Cardiovasc Dis. 32(6):1402-1409
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Alternative Title:Nutr Metab Cardiovasc Dis
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Description:Background and Aims
Prior studies suggest a positive association between dietary AGEs and adverse health outcomes but have not well-characterized AGEs intake and its association with mortality in a general adult population in the United States.
Methods and Results
We included 5,474 adults with diabetes from the 2003 to 2018 National Health and Nutrition Examination Survey, a nationally representative sample of the non-institutionalized civilian population in the United States. Concordance to dietary guidelines (Healthy Eating Index 2015 [HEI-2015]) and intake of the AGE Nɛ-(carboxymethyl)lysine (CML) were estimated using an existing database and two 24-hour food recalls. Multivariable Cox regression evaluated the association between AGEs intake and all-cause mortality. A secondary analysis measured CML, Nɛ-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MGH1) from an alternative database.
Conclusion
While dietary AGEs intake was associated with concordance to dietary guidelines, it was not significantly associated with all-cause mortality among adults with diabetes. Further research may consider other health outcomes as well as the evaluating specific contribution of dietary AGEs to overall AGEs burden.
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Pubmed ID:35282981
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Pubmed Central ID:PMC9167219
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