Assessment of poliovirus antibody seroprevalence in polio high risk areas of West Africa

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Guindo, Oumar ; Mach, Ondrej ; Doumbia, Seydou ; Ekra, Daniel K. ; Beavogui, Abdoul H. ; Weldon, William C. ; Oberste, M. Steven ; Sutter, Roland W.
• Description:
  We conducted a serological survey of anti-polio antibodies in polio high-risk areas of Mali, Guinea and Cote d'Ivoire to assess risk of future poliovirus outbreaks. Random community sampling of children 6-11 and 36-48 months-old was conducted; neutralizing antibodies against poliovirus were detected using microneutralization assay. We analysed 1059/1064 (99.5%) of enrolled children. Seroprevalence to poliovirus type 1 (PV1) across all age groups and locations ranged between 92 and 100%, for PV2 it was 77-100%, and 89-95% for PV3. PV2 seroprevalence in the younger age group in Guinea and Cote d'Ivoire was <80%. History of <4 polio vaccine doses and acute malnutrition were associated with seronegativity (OR = 2.1 CI95% = 1.5-3.1, OR = 1.8 CI95% = 1.1-3.3 respectively). The risk of poliovirus outbreak following importation is low because of high population immunity to PV1, however, due to large cohort of PV2 seronegative children any future detection of vaccine-derived poliovirus type 2 requires urgent response to arrest rapid spread.
• Subjects:
  Antibodies, Neutralizing Antibodies, Viral Child Child, Preschool Disease Outbreaks Female Humans Male Poliovirus Seroepidemiologic Studies Vaccination

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• Source:
  Vaccine. 36(8):1027-1031
• Pubmed ID:
  29358054
• Pubmed Central ID:
  PMC9131301
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  Cote d'Ivoire ; Guinea ; West Africa
• Volume:
  36
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:360d44f4c6dea091025da450744a905beebbe4d1b2c4a386ded13531ea089779
• Download URL:
  https://stacks.cdc.gov/view/cdc/119186/cdc_119186_DS1.pdf
• File Type:
  [PDF - 375.36 KB ]