Details:

Alternative Title:
Biol Psychiatry Cogn Neurosci Neuroimaging
Personal Author:
Fitzgerald, Jacklynn M. ; Webb, Elisabeth Kate ; Weis, Carissa N. ; Huggins, Ashley A. ; Bennett, Ken P. ; ... More +
Fitzgerald, Jacklynn M. ; Webb, Elisabeth Kate ; Weis, Carissa N. ; Huggins, Ashley A. ; Bennett, Ken P. ; Miskovich, Tara A. ; Krukowski, Jessica L. ; deRoon-Cassini, Terri A. ; Larson, Christine L. Less -
Description:
Background:

Posttraumatic Stress Disorder (PTSD) is a debilitating disorder and there is no current accurate prediction of who develops it after trauma. Neurobiologically, individuals with chronic PTSD exhibit aberrant resting-state functional connectivity (rsFC) between the hippocampus and other brain regions (e.g., amygdala, prefrontal cortex, posterior cingulate), and these aberrations correlate with severity of illness. Prior small-scale research (n < 25) has also shown that hippocampal-rsFC measured acutely after trauma is predictive of future severity using an ROI-based approach. While a promising biomarker, to-date no study has employed a data-driven approach to test whole-brain hippocampal-FC patterns in forecasting the development of PTSD symptoms.

Methods:

Ninety-eight adults at risk of PTSD were recruited from the emergency department following traumatic injury and completed resting functional magnetic resonance imaging (rsfMRI; 8min) within 1-month; 6-months later they completed the Clinician-Administered PTSD Scale (CAPS-5) for assessment of PTSD symptom severity. Whole-brain rsFC values with bilateral hippocampi were extracted (CONN) and used in a machine learning kernel ridge regression analysis (PRoNTo); both a k-folds (k=10) and 70/30 testing vs. training split approach were used for cross-validation (1,000 iterations to bootstrap confidence intervals for significance values).

Results:

Acute hippocampal-rsFC significantly predicted CAPS-5 scores at 6-months (r=0.30, p=0.006; MSE=120.58, p=0.006; R2=0.09, p=0.025). In post-hoc analyses, hippocampal-rsFC remained significant after controlling for demographics, PTSD symptoms at baseline, and depression, anxiety, and stress severity at 6-months (B=0.59, SE=0.20, p=0.003).

Conclusions:

Findings suggest functional connectivity of the hippocampus across the brain acutely after traumatic injury is associated with prospective PTSD symptom severity.


Subjects:
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Adult Brain Hippocampus Humans Magnetic Resonance Imaging Prospective Studies Stress Disorders, Post-Traumatic
Source:
Biol Psychiatry Cogn Neurosci Neuroimaging. 7(2):139-149
Pubmed ID:
34478884
Pubmed Central ID:
PMC8825698
Document Type:
Journal Article
Funding:
TL1 TR001437/TR/NCATS NIH HHSUnited States/ ; R01 MH106574/MH/NIMH NIH HHSUnited States/ ; U01 CE002944/CE/NCIPC CDC HHSUnited States/ ; UL1 TR001436/TR/NCATS NIH HHSUnited States/ ; U01 NS088034/NS/NINDS NIH HHSUnited States/
TL1 TR001437/TR/NCATS NIH HHSUnited States/ ; R01 MH106574/MH/NIMH NIH HHSUnited States/ ; U01 CE002944/CE/NCIPC CDC HHSUnited States/ ; UL1 TR001436/TR/NCATS NIH HHSUnited States/ ; U01 NS088034/NS/NINDS NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:54bd06ab6536707d4603882777f6ae5660d3540ccb04fca0859e1bc51e45a31a
Download URL:
https://stacks.cdc.gov/view/cdc/119179/cdc_119179_DS1.pdf
File Type:

Supporting Files

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