Targeted Screening for Chronic Q Fever, the Netherlands

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Reukers, Daphne F.M. ; de Boer, Pieter T. ; Loohuis, Alfons O. ; Wever, Peter C. ; Bleeker-Rovers, Chantal P. ; van Gageldonk-Lafeber, Arianne B. ; van der Hoek, Wim ; Timen, Aura
• Description:
  Early detection of and treatment for chronic Q fever might prevent potentially life-threatening complications. We performed a chronic Q fever screening program in general practitioner practices in the Netherlands 10 years after a large Q fever outbreak. Thirteen general practitioner practices located in outbreak areas selected 3,419 patients who had specific underlying medical conditions, of whom 1,642 (48%) participated. Immunofluorescence assay of serum showed that 289 (18%) of 1,642 participants had a previous Coxiella burnetii infection (IgG II titer >1:64), and 9 patients were suspected of having chronic Q fever (IgG I y titer >1:512). After medical evaluation, 4 of those patients received a chronic Q fever diagnosis. The cost of screening was higher than estimated earlier, but the program was still cost-effective in certain high risk groups. Years after a large Q fever outbreak, targeted screening still detected patients with chronic Q fever and is estimated to be cost-effective.
• Subjects:
  Antibodies, Bacterial Humans Immunoglobulin G Q Fever
• Source:
  Emerg Infect Dis. 2022; 28(7):1403-1409
• Pubmed ID:
  35731163
• Pubmed Central ID:
  PMC9239892
• Document Type:
  Journal Article
• Place as Subject:
  Netherlands
• Volume:
  28
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:299e52986e73769612bc441e3b18385435c306710b7466d79633f0220759a6be
• Download URL:
  https://stacks.cdc.gov/view/cdc/118910/cdc_118910_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]