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False-positive investigation toolkit : a resource for mycobacteriology laboratories 2019
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Description:False-positive Mycobacterium tuberculosis complex (MTBC) results can be difficult to identify, investigate, and resolve. False-positive results often have serious implications for patient isolation, patient therapy, contact investigations, and unnecessary laboratory testing. Errors leading to falsepositive results can be classified as pre-analytic, analytic, or post-analytic. In any mycobacteriology laboratory, cross-contamination, mislabeling errors, specimen mix-ups, and use of nonsterile reagents can cause the inadvertent transfer of bacilli from one specimen or culture to another specimen or culture.
In 1997, the Centers for Disease Control and Prevention (CDC) and the Association of State and Territorial Public Health Laboratory Directors [now known as Association of Public Health Laboratories (APHL)] developed a video and 28-page booklet titled “Recognition and Prevention of False-Positive Test Results in Mycobacteriology —A Laboratory Training Program.” The program was designed to help laboratorians recognize and prevent false-positive test results in mycobacteriology. Since 1997, the program has not been updated and similar publications have been limited in recent years.
This project, the False-Positive Investigation Toolkit, was developed to provide mycobacteriology staff with updated resources to recognize potential false-positive results and to assist staff in falsepositive investigations.
The toolkit’s primary audience is mycobacteriology laboratory supervisors, technologists, and qualityassurance staff members. In addition, TB Control programs and healthcare providers may also find this information beneficial when investigating potential false-positive laboratory results.
Publication date from documenrt properties.
False-Positive-Toolkit.pdf
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Content Notes:I. Introduction -- II. Glossary -- III. Pre-Analytic, Analytic, and Post-Analytic Prevention Practices -- IV. Laboratory Monitoring -- V. Monitoring for False-Positive Results Outside the Laboratory -- VI. Initial Communication of a Potential False-Positive -- VII. Laboratory Areas for Investigation when a Potential False-Positive Result is Suspected -- VIII. Actions Taken as a Result of a False-Positive Investigation -- IX. Job-Aids -- X. Posters -- XI. Templates -- XII. References -- XIII. Acknowledgments.
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