Unravelling innervation of pancreatic islets

Details

• Alternative Title:
  Diabetologia
• Personal Author:
  Hampton, Rollie F. ; Jimenez-Gonzalez, Maria ; Stanley, Sarah A.
• Description:
  The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, investigated the contribution of sympathetic, parasympathetic and sensory neural pathways to glucose control, and begun to determine how the structure and function of pancreatic nerves are disrupted in metabolic disease. Now, state-of-the art techniques such as 3D imaging of pancreatic innervation and targeted in vivo neuromodulation provide further insights into the anatomy and physiological roles of islet innervation. Here, we provide a summary of the published work on the anatomy of pancreatic islet innervation, its roles, and evidence for disordered islet innervation in metabolic disease. Finally, we discuss the possibilities offered by new technologies to increase our knowledge of islet innervation and its contributions to metabolic regulation.
• Subjects:
  • Humans
  • Islets of Langerhans Transplantation
  • Islets of Langerhans
  • Pancreas
• Source:
  Diabetologia. 65(7):1069-1084
• Pubmed ID:
  35348820
• Pubmed Central ID:
  PMC9205575
• Document Type:
  Journal Article
• Funding:
  1930163/CD/ODCDC CDC HHSUnited States/ ; W81XWH-20-1-0345/U.S. Department of Defense/ ; F31 DK129016/DK/NIDDK NIH HHSUnited States/ ; R01NS097184/RG/CSR NIH HHSUnited States/ ; #1-17-ACE-31/American Diabetes Association/
• Volume:
  65
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/118446/cdc_118446_DS1.pdf
• File Type:
  [PDF - 1.04 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:32852ef52b8c4230b8e5129706e1c3b2deae45a6189a0b80a6ae2897ac8b33a6