Details:

Alternative Title:
Prev Chronic Dis
Personal Author:
Barger, Steven D. ; Struve, Gabrielle C.
Barger, Steven D. ; Struve, Gabrielle C. Less -
Description:
Introduction

Although an association between depression and incident cardiovascular disease (CVD) risk has been established, no US studies have quantified this association using standard primary care assessments or among younger adults who are not routinely screened for CVD risk. We estimated the association of mild and major depression with 1) 10-year atherosclerotic CVD (ASCVD) risk for people aged 40 to 79 years and 2) high lifetime CVD risk prevalence for people aged 20 to 39 years.

Methods

We conducted a cross-sectional analysis of data from the 2005–2018 National Health and Nutrition Examination Survey for adults aged 20 to 39 years (n = 10,588) and adults aged 40 to 79 years (n = 16,848). We used the Patient Health Questionnaire-9 [PHQ-9] to classify no depression (PHQ-9 score, 0–4), mild depression (PHQ-9 score, 5–9) and major depression (PHQ-9 score ≥10).

Results

Among women aged 40 to 79, ASCVD absolute risk was 6.0% for no depression, 6.9% for mild depression, and 7.6% for major depression (P < .001 vs no depression). Among men aged 40 to 79, the corresponding absolute ASCVD risks were 9.9%, 11.1%, and 11.3%, respectively (P < .001 vs no depression). High lifetime CVD risk prevalence for women aged 20 to 39 was 41.9% for no depression, 53.2% for mild depression, and 66.5% for major depression (P < .001 vs no depression). For men aged 20–39 the corresponding high lifetime risk percentages were 53.3%, 64.8%, and 74.4% respectively (P < .001 vs no depression).

Conclusion

Mild and major depression are associated with elevated 10-year ASCVD risk and substantially elevated lifetime CVD risk among younger people ineligible for ASCVD risk assessment. Jointly addressing depression and CVD risk and extending prevention efforts to younger adults are warranted.


Subjects:
[+]
Adult Cardiovascular Diseases Cross-Sectional Studies Depression Female Humans Male Nutrition Surveys Original Research Risk Assessment Risk Factors
Source:
Prev Chronic Dis. 2022; 19
Pubmed ID:
35617679
Pubmed Central ID:
PMC9165473
Document Type:
Journal Article
Collection(s):
Preventing Chronic Disease
Main Document Checksum:
[+]
urn:sha256:0cb2e50dad31463b0d9f8c89502be0bd78051fdce4e6252e8ef4cff202a310c0
Download URL:
https://stacks.cdc.gov/view/cdc/118367/cdc_118367_DS1.pdf
File Type:

Supporting Files

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