Indirect Mediators of Systemic Health Outcomes Following Nanoparticle Inhalation Exposure

Details

• Alternative Title:
  Pharmacol Ther
• Personal Author:
  Mostovenko, Ekaterina ; Canal, Christopher G. ; Cho, MiJin ; Sharma, Kirti ; Erdely, Aaron ; Campen, Matthew J. ; Ottens, Andrew K.
• Description:
  The growing field of nanoscience has shed light on the wide diversity of natural and anthropogenic sources of nano-scale particulates, raising concern as to their impacts on human health. Inhalation is the most robust route of entry, with nanoparticles (NPs) evading mucociliary clearance and depositing deep into the alveolar region. Yet, impacts from inhaled NPs are evident far outside the lung, particularly on the cardiovascular system and highly vascularized organs like the brain. Peripheral effects are partly explained by the translocation of some NPs from the lung into the circulation; however, other NPs largely confined to the lung are still accompanied by systemic outcomes. Omic research has only just begun to inform on the complex myriad of molecules released from the lung to the blood as byproducts of pulmonary pathology. These indirect mediators are diverse in their molecular make-up and activity in the periphery. The present review examines systemic outcomes attributed to pulmonary NP exposure and what is known about indirect pathological mediators released from the lung into the circulation. Further focus was directed to outcomes in the brain, a highly vascularized region susceptible to acute and longer-term outcomes. Findings here support the need for big-data toxicological studies to understand what drives these health outcomes and better predict, circumvent, and treat the potential health impacts arising from NP exposure scenarios.
• Subjects:
  Article Humans Inhalation Exposure Inhalation Toxicology Lung Nanomaterials Nanoparticles Nanotubes Neurotoxicology Outcome Assessment, Health Care Particle Size Peptidomics

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• Source:
  Pharmacol Ther. 235:108120
• Pubmed ID:
  35085604
• Pubmed Central ID:
  PMC9189040
• Document Type:
  Journal Article
• Funding:
  R56 ES014639/ES/NIEHS NIH HHSUnited States/ ; R01 AG070776/AG/NIA NIH HHSUnited States/ ; R21 OH010495/OH/NIOSH CDC HHSUnited States/ ; P20 GM130422/GM/NIGMS NIH HHSUnited States/ ; R01 OH010828/OH/NIOSH CDC HHSUnited States/ ; R01 ES014639/ES/NIEHS NIH HHSUnited States/
• Volume:
  235
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:814509901c057a83814a0b24b2e24af7ceff01d6e6ec7efe6119abf8a2469664
• Download URL:
  https://stacks.cdc.gov/view/cdc/118274/cdc_118274_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]