Details:

Alternative Title:
Curr Allergy Asthma Rep
Publisher's site:
http://dx.doi.org/10.1007/s11882-019-0882-2
Personal Author:
Sheats, M. Katie ; Davis, Kaori U. ; Poole, Jill A.
Sheats, M. Katie ; Davis, Kaori U. ; Poole, Jill A. Less -
Description:
Purpose of Review

Farmers are routinely exposed to organic dusts and aeroallergens that can have adverse respiratory health effects including asthma. Horses are farm-reared large animals with similar exposures and can develop equine asthma syndrome (EAS). This review aims to compare the etiology, pathophysiology, and immunology of asthma in horses compared to farmers and highlights the horse as a potential translational animal model for organic dust-induced asthma in humans.

Recent Findings

Severe EAS shares many clinical and pathological features with various phenotypes of human asthma including allergic, non-allergic, late onset, and severe asthma. EAS disease features include variable airflow obstruction, cough, airway hyperresponsiveness, airway inflammation/remodeling, neutrophilic infiltrates, excess mucus production, and chronic innate immune activation.

Summary

Severe EAS is a naturally occurring and biologically relevant, translational animal disease model that could contribute to a more thorough understanding of the environmental and immunologic factors contributing to organic dust-induced asthma in humans.


Subject:
[+]
Animals Article Asthma Bronchitis Environmental Exposure Equine Asthma Syndrome Farmers Horse Diseases Horses Humans Innate Immunity Neutrophilic Asthma Occupational Asthma Organic Dust
Source:
Curr Allergy Asthma Rep. 19(11):50
Pubmed ID:
31599358
Pubmed Central ID:
PMC9116535
Document Type:
Journal Article
Funding:
R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/
R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/ Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:06799802a533ceeee29439509dc4cf4a60626979d3a5e0369d19185181ef72e3
Download URL:
https://stacks.cdc.gov/view/cdc/117635/cdc_117635_DS1.pdf
File Type:

Supporting Files

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