Comparative Review of Asthma in Farmers and Horses

Details

• Journal Article:
  Curr Allergy Asthma Rep
• Personal Author:
  Sheats, M. Katie ; Davis, Kaori U. ; Poole, Jill A.
• Description:
  Purpose of Review
  
  Farmers are routinely exposed to organic dusts and aeroallergens that can have adverse respiratory health effects including asthma. Horses are farm-reared large animals with similar exposures and can develop equine asthma syndrome (EAS). This review aims to compare the etiology, pathophysiology, and immunology of asthma in horses compared to farmers and highlights the horse as a potential translational animal model for organic dust-induced asthma in humans.
  
  Recent Findings
  
  Severe EAS shares many clinical and pathological features with various phenotypes of human asthma including allergic, non-allergic, late onset, and severe asthma. EAS disease features include variable airflow obstruction, cough, airway hyperresponsiveness, airway inflammation/remodeling, neutrophilic infiltrates, excess mucus production, and chronic innate immune activation.
  
  Summary
  
  Severe EAS is a naturally occurring and biologically relevant, translational animal disease model that could contribute to a more thorough understanding of the environmental and immunologic factors contributing to organic dust-induced asthma in humans.
  
  
• Subjects:
  Asthma Bronchitis Dust Environmental Exposure Farmers Horses Occupational Health Respiratory System Respiratory Tract Diseases
• Keywords:
  Author Keywords: Equine Asthma Syndrome; Occupational Asthma; Organic Dust; Innate Immunity; Neutrophilic Asthma; Bronchitis Farmers; Agricultural Industry; Agriculture; Organic Dusts; Asthma; Animals; Animal Handlers; Immunology; Allergic Reactions; Allergies; Immune Reaction;
• Source:
  Curr Allergy Asthma Rep. 19(11):50
• Pubmed ID:
  31599358
• Pubmed Central ID:
  PMC9116535
• Document Type:
  Text
• Funding:
  R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; North Carolina ; OSHA Region 4 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15 pdf pages
• Volume:
  19
• Issue:
  11
• NIOSHTIC Number:
  nn:20065180
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:66d261c80472a2a6ac3183abd3047ec77471f8e26822ab4bfb52b7ce97d75fdd568a419881fdbf4533f8665e3d80f7980d7a2f3d9f4b2da81dbd9d48b8c75163
• Download URL:
  https://stacks.cdc.gov/view/cdc/117635/cdc_117635_DS1.pdf
• File Type:
  [PDF - 395.92 KB ]