Comparative Review of Asthma in Farmers and Horses

Details

• Journal Article:
  Current Allergy & Asthma Reports
• Personal Author:
  Sheats, M. Katie ; Davis, Kaori U. ; Poole, Jill A.
• Description:
  Purpose of Review: Farmers are routinely exposed to organic dusts and aeroallergens that can have adverse respiratory health effects including asthma. Horses are farm-reared large animals with similar exposures and can develop equine asthma syndrome (EAS). This review aims to compare the etiology, pathophysiology, and immunology of asthma in horses compared to farmers and highlights the horse as a potential translational animal model for organic dust-induced asthma in humans. Recent Findings: Severe EAS shares many clinical and pathological features with various phenotypes of human asthma including allergic, non-allergic, late onset, and severe asthma. EAS disease features include variable airflow obstruction, cough, airway hyperresponsiveness, airway inflammation/remodeling, neutrophilic infiltrates, excess mucus production, and chronic innate immune activation. Summary: Severe EAS is a naturally occurring and biologically relevant, translational animal disease model that could contribute to a more thorough understanding of the environmental and immunologic factors contributing to organic dust-induced asthma in humans. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Asthma Asthma, Occupational Bronchitis Dust Environmental Exposure Farmers Horses Hypersensitivity Immune System Occupational Health Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Author Keywords: Equine Asthma Syndrome; Occupational Asthma; Organic Dust; Innate Immunity; Neutrophilic Asthma; Bronchitis Farmers; Agricultural Industry; Agriculture; Organic Dusts; Asthma; Animals; Animal Handlers; Immunology; Allergic Reactions; Allergies; Immune Reaction;
• Source:
  Curr Allergy Asthma Rep 2019 Nov; 19(11):50
• ISSN:
  1529-7322
• Pubmed ID:
  31599358
• Pubmed Central ID:
  PMC9116535
• Document Type:
  Text
• Funding:
  R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; North Carolina ; OSHA Region 4 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15 pdf pages
• Volume:
  19
• Issue:
  11
• NIOSHTIC Number:
  nn:20065180
• Contact Point Address:
  M. Katie Sheats, Comparative Medicine Institute, Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA
• Email:
  mkpeed@ncsu.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:66d261c80472a2a6ac3183abd3047ec77471f8e26822ab4bfb52b7ce97d75fdd568a419881fdbf4533f8665e3d80f7980d7a2f3d9f4b2da81dbd9d48b8c75163
• Download URL:
  https://stacks.cdc.gov/view/cdc/117635/cdc_117635_DS1.pdf
• File Type:
  [PDF - 395.92 KB ]