Respiratory Health, Allergies, and the Farm Environment: Design, Methods and Enrollment in the Observational Wisconsin Infant Study Cohort (WISC): A Research Proposal

Details

• Personal Author:
  Barnes KL ; Bendixsen CG ; Cole D ; Dresen A ; Evans MD ; Gangnon RE ; Gern JE ; Johnson T ; Keifer MC ; Koepel TK ; Meece J ; Olson BF ; Seroogy CM ; VanWormer JJ
• Description:
  Epidemiologic and cross-sectional studies suggest that early life farming and animal exposures are associated with major health benefits, influencing immune development and modifying the subsequent risk of allergic diseases, including asthma. The Wisconsin Infant Study Cohort (WISC) study was established in central Wisconsin to test the hypothesis that early life animal farm exposures are associated with distinct innate immune cell maturation trajectories, decreased allergen sensitization and reduced respiratory viral illness burden during the first 2 years of life. Beginning in 2013, a total of 240 families have been enrolled, 16,522 biospecimens have been collected, and 4098 questionnaires have been administered and entered into a secure database. Study endpoints include nasal respiratory virus identification and respiratory illness burden score, allergic sensitization, expression of allergic disease, and anti-viral immune response maturation and profiles. The WISC study prospective design, broad biospecimen collections, and unique US rural community will provide insights into the role of environmental exposures on early life immune maturation profiles associated with protection from allergic sensitization and significant respiratory viral disease burden. The WISC study findings will ultimately inform development of new strategies to promote resistance to severe respiratory viral illnesses and design primary prevention approaches for allergic diseases for all infants. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Asthma Asthma, Occupational Environmental Exposure Epidemiology Family Farmers Hypersensitivity Immune System Occupational Health Pregnancy Respiratory System Safety Surveys And Questionnaires

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• Keywords:
  Allergens Author Keywords: Allergies Birth Cohort Children Cross Sectional Studies Environmental Exposure Families Farm Farm Workers Health Effects Immune System Questionnaires Respiratory Health Respiratory Virus Sensitization

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• ISSN:
  1756-0500
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 10 ; OSHA Region 5 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• NIOSHTIC Number:
  nn:20056517
• Citation:
  BMC Res Notes 2019 Jul; 12:423
• Contact Point Address:
  Christine M. Seroogy, Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705-2275
• Email:
  cmseroogy@wisc.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Minnesota
• Peer Reviewed:
  True
• Start Date:
  20110930
• Source Full Name:
  BMC Research Notes
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8eaf4e03455c73a63a4ecd8978c83c274ffd9a10a2f93f213030328f0f7c96c34c0bb58180c1d36b13f42fcccf9cf2a63e004803dac2727893882fead1f61886
• Download URL:
  https://stacks.cdc.gov/view/cdc/214114/cdc_214114_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]